Results 121 to 130 of about 4,571,499 (346)
FEBS Open Bio, EarlyView.Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao +7 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
F-theory on quotients of elliptic Calabi-Yau threefolds
Journal of High Energy Physics, 2019 In this work we consider quotients of elliptically fibered Calabi-Yau threefolds by freely acting discrete groups and the associated physics of F-theory compactifications on such backgrounds.
Lara B. Anderson +2 more
doaj +1 more source
The Physical Action Theory of Trying [PDF]
, 2018 I introduce the idea that an act of trying is identical to some physical action. Identity requires (at least) one-one correspondence: for each token trying act, there would have be one and only one token physical act (of course, namely itself) with which it is identical.
openaire +2 more sources
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
QCD and Nuclear Physics. How to Explain the Coincidence Between the Action Radius of Nuclear Forces and the Characteristic Scale of the Neutron-Neutron Electrostatic Interaction? [PDF]
, 2015 A. Godizov
openalex +1 more source
Card games are effective tools to enhance foundation year health and safety inductions
FEBS Open Bio, EarlyView.A series of three card games was developed to actively deliver health and safety education to foundation year students. Most students reported positive responses regarding their enjoyment (89.9 %) and learning (74.7 %) from all games evaluated. Data revealed significant improvements in health and safety knowledge (P < 0.0001).
Rumana Rafiq +4 more
wiley +1 more source
The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored. Objectives To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.
Ellie McCluey +17 more
wiley +1 more source
Towards precision charm physics with a mixed action
, 2022 Alessandro Conigli +5 more
openalex +2 more sources