Results 131 to 140 of about 5,555,873 (373)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Constraining the Noncommutative Spectral Action via Astrophysical Observations

, 2010
The noncommutative spectral action extends our familiar notion of commutative spaces, using the data encoded in a spectral triple on an almost commutative space. Varying a rather simple action, one can derive all of the standard model of particle physics
A. Connes, A. H. Chamseddine, Joseph Ochoa, L. D. Landau, Mairi Sakellariadou, William Nelson   +5 more
core   +1 more source

Least Action Principle in Physics

, 2018
We learn physics by starting it from classical problem, where Newton's laws govern the classical physics. In high school or often in early physics in undergraduate, we still solve classic problem with newton's equation of motion. In this article, I will show that there's more alternative way to see classical problem instead seeing from Newton's law ...
openaire   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Light meson physics and scale setting from a mixed action with Wilson twisted mass valence quarks [PDF]

, 2022
Gregorio Herdoíza, Andrea Bussone, Alessandro Conigli, Julien Frison, Carlos Pena, David Preti, José Ángel Romero, Alejandro Saez, Javier Ugarrio   +8 more
openalex   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Analog gravity from field theory normal modes?

, 2001
We demonstrate that the emergence of a curved spacetime ``effective Lorentzian geometry'' is a common and generic result of linearizing a field theory around some non-trivial background. This investigation is motivated by considering the large number of `
, Alarcón S G, Barceló C, Barceló C, Barton G, Birrell N D, Bondi H, Carlos Barceló, Chapline G, Corley S, Corley S, Courant R, de Felice F, de Lorenci V A, DeWitt B S, Dittrich W, Donoghue J F, Donoghue J F, Donoghue J F, Donoghue J F, Donoghue J F, Feynman R P, Fischer U R, Fischer U R, Garay L J, Garay L J, Gies H, Gordon W, Hawking S W, Hawking S W, Hehl F W, Ito K, Itzykson C, Jacobson T, Jacobson T A, Jacobson T A, Kopnin N B, Kopnin N B, Leonhardt U, Leonhardt U, Leonhardt U, Liberati S, Liberati S, Liberati S, Matarrese S, Matarrese S, Matarrese S, Matt Visser, Mijic M B, Novello M, Novello M, Obukhov Y N, Obukhov Y N, Plebañski J, Regge T, Reznik B, Reznik B, Reznik B, Sakharov A, Scharnhorst K, Skrotskii G V, Stefano Liberati, Stephens G J, Unruh W G, Utiyama R, Visser M, Visser M, Visser M, Visser M, Visser M, Visser M, Volovik G E, Volovik G E, Volovik G E, Volovik G E, Volovik G E, Volovik G E, Volovik G E, Volovik G E Links between gravity, Weinberg S, Weinberg S   +80 more
core   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

The principle of least action and teleological explanation in physics [PDF]

, 2023
David Glick
openalex   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source