Results 211 to 220 of about 762,494 (319)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

<i>Track-A-Worm 2.0</i>: A Software Suite for Quantifying Properties of <i>C. elegans</i> Locomotion, Bending, Sleep, and Action Potentials. [PDF]

eNeuro
Vedantham K, Niu L, Ma R, Connelly L, Nagella A, Wang SJ, Wang ZW.   +6 more
europepmc   +1 more source

Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials. [PDF]

Front Cell Neurosci, 2023
Grasskamp AT, Jusyte M, McCarthy AW, Götz TWB, Ditlevsen S, Walter AM.   +5 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Axons compensate for biophysical constraints of variable size to uniformize their action potentials. [PDF]

PLoS Biol
Brunner J, Arszovszki A, Tarcsay G, Szabadics J.   +3 more
europepmc   +1 more source

Plant electrophysiology with conformable organic electronics: Deciphering the propagation of Venus flytrap action potentials. [PDF]

Sci Adv, 2023
Armada-Moreira A, Dar AM, Zhao Z, Cea C, Gelinas J, Berggren M, Costa A, Khodagholy D, Stavrinidou E.   +8 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials. [PDF]

J Gen Physiol
Köster PA, Leipold E, Tigerholm J, Maxion A, Namer B, Stiehl T, Lampert A.   +6 more
europepmc   +1 more source

Acoustically Evoked Compound Action Potentials Recorded From Cochlear Implant Users With Preserved Acoustic Hearing. [PDF]

Ear Hear, 2023
Kim JS, Brown CJ.
europepmc   +1 more source

Cellular excitability and ns-pulsed electric fields: Potential involvement of lipid oxidation in the action potential activation

, 2023
Lea Rems, Aurianne Rainot, Daniel Wiczew, Natalia Szulc, Mounir Tarek   +4 more
openalex   +1 more source