Results 211 to 220 of about 749,554 (288)

Modulatory Impact of Oxidative Stress on Action Potentials in Pathophysiological States: A Comprehensive Review. [PDF]

Antioxidants (Basel)
Mahapatra C, Thakkar R, Kumar R.
europepmc   +1 more source

Photolipid excitation triggers depolarizing optocapacitive currents and action potentials

, 2023
Bassetto CAZ, Pfeffermann J, Yadav R, Strassgschwandtner S, Glasnov T, Bezanilla F, Pohl P.   +6 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Modelling pacemaker oscillations in lymphatic muscle cells: lengthened action potentials by two distinct system effects. [PDF]

R Soc Open Sci
Hancock EJ, Macaskill C, Zawieja SD, Davis MJ, Bertram CD.   +4 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Electrically evoked compound action potentials are associated with the site of intracochlear stimulation. [PDF]

Eur Arch Otorhinolaryngol
Weiss NM, Breitsprecher T, Völter C, Lammers M, Van de Heyning P, Dazert S, Van Rompaey V.   +6 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Memory-electroluminescence for multiple action-potentials combination in bio-inspired afferent nerves. [PDF]

Nat Commun
Wang K, Liao Y, Li W, Li J, Su H, Chen R, Park JH, Zhang Y, Zhou X, Wu C, Liu Z, Guo T, Kim TW.   +12 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Intelligent in-cell electrophysiology: Reconstructing intracellular action potentials using a physics-informed deep learning model trained on nanoelectrode array recordings. [PDF]

Nat Commun
Rahmani K, Yang Y, Foster EP, Tsai CT, Meganathan DP, Alvarez DD, Gupta A, Cui B, Santoro F, Bloodgood BL, Yu R, Forro C, Jahed Z.   +12 more
europepmc   +1 more source