Results 111 to 120 of about 4,899,620 (258)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Online human action recognition based on skeletal data for human-robot collaboration scenarios

open access: yes
reservedHuman Action Recognition (HAR) is a relevant research area of computer vision that deals with the recognition and classification of the human actions from data captured by sensors such as cameras or wearable sensors.
MARCHESINI, ANNA
core  

Feature Hallucination for Self-supervised Action Recognition

open access: yes
Understanding human actions in videos requires more than raw pixel analysis; it relies on high-level semantic reasoning and effective integration of multimodal features.
Koniusz, Piotr, Wang, Lei
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Action learning, action research: Towards greater collaboration amongst networks

open access: yes, 2018
Recent conversations with a variety of action learning and action research practitioners around the world have identified a growing desire for collaboration between networks.
Bradley, Colin
core  

Perceptual Perspective Taking and Action Recognition

open access: yesInternational Journal of Advanced Robotic Systems, 2008
Robots that operate in social environments need to be able to recognise and understand the actions of other robots, and humans, in order to facilitate learning through imitation and collaboration.
Matthew Johnson, Yiannis Demiris
doaj  

Interaction-Aware Scene Debiasing for Action Recognition

open access: yesIEEE Access
Deep learning models for action recognition remain challenged by scene biases as they prioritize easily learnable scene representations over the actual actor’s motion patterns.
Randy Cahya Wihandika   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

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