Results 91 to 100 of about 54,356,744 (262)

Facilitated action research: Enhancing the teaching of classroom drama

, 2013
This paper argues for facilitated action research as an effective way of supporting teacher professional learning in drama. It also recognises that the need for support identified in a past study remains current resulting in the facilitated action ...
Perry, Rachel
core  

Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions

Nature Communications, 2019
OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contribute ...
James R. Birtley, Mohammad Alomary, Elisa Zanini, Jane Antony, Zachary Maben, Grant C. Weaver, Claudia Von Arx, Manuela Mura, Aline T. Marinho, Haonan Lu, Eloise V. N. Morecroft, Evdoxia Karali, Naomi E. Chayen, Edward W. Tate, Mollie Jurewicz, Lawrence J. Stern, Chiara Recchi, Hani Gabra   +17 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Peer assisted teaching scheme and Participative Action Learning Action Research: A winning combination

, 2015
This paper demonstrates synergetic influences of systems thinking upon a third cycle of action research aimed at improve teaching skills and the student experience.
Cameron, Leone Carol
core  

Effectiveness of a state university extension program on pedagogical action research

, 2021
This paper described the effectiveness of the training program as extension project of a state university titled “Mindful Change: A Capacity Building Program for Pedagogical Action Research”.
Digo, Gerry S.
core  

Pan-cancer analysis reveals immunological and prognostic significance of CCT5 in human tumors

Scientific Reports
The chaperonin containing TCP1 subunit 5 (CCT5) is believed to function as a tumor driver. However, a systematic pan-cancer analysis of CCT5 is still lacking. Therefore, this study aimed to identify the potential role of CCT5 in different types of tumors.
Md. Zabir Ahmed, Md Mohtasim Billah, Jannatul Ferdous, Shoriful Islam Antar, Abdullah Al Mamun, Md. Jubayer Hossain   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Using Action Research in Practice: Project and Knowledge Management Studies

, 2017
The aim of this paper is to describe a direct and personal account of the issues and challenges that occurred in three action research projects that were part of a doctoral research programme.
Duffield, Stephen Mark
core  

Roof renewal disparities widen the equity gap in residential wildfire protection

Nature Communications
Wildfires are having disproportionate impacts on U.S. households. Notably, in California, over half of wildfire-destroyed homes (54%) are in low-income areas.
Sebastian Reining, Moritz Wussow, Chad Zanocco, Dirk Neumann   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source