Results 151 to 160 of about 2,466,856 (269)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Moving from "damage-centered" research to "family-centered" participatory action research for systems change: a call to action for developmental and family scientists. [PDF]

Front Psychol
Vesely CK, Letiecq BL, Zhang X, Family Council for Equity in Education.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Involving Citizens in Integrated Care. Lessons Learned Through Participatory Action Research in Three Communities in the Netherlands. [PDF]

Int J Integr Care
Rutten GM, van Wijk E, Sleijster S, Oostra DL, Roenhorst J, Kleinjan M, Laurant M.   +6 more
europepmc   +1 more source

Action in research and research in action: what intertwining?

L'édition 2023 de la Journée des jeunes chercheur.e.s de l'Institut de Géographie de Paris [JIG] souhaitait interroger les liens entre la recherche et les autres contextes de l’action - professionnels, militants, politiques - qu'elle cherche à analyser et avec lesquels, en conséquence, elle interagit, voire s'imbrique.
Buzaré, Margot, Fruiquière, Marie, Gauthier, Marie-Hélène, Kunysz, Pavel, Mawussi, Ayité, Poupeau, Coline, Raymond, Léo, Reville, Léa, Sebillotte, Oriane, Schmoll, Camille   +9 more
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Construction and implementation of a death education program for nursing interns: an action research study. [PDF]

BMC Med Educ
Liu J, Guo X, Hou B, Xu Y, Hong M, Xu N, Zhang W, Xia Y, Lou Y.   +8 more
europepmc   +1 more source

Qualitative Research in Action [PDF]

, 2002
openaire   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Fostering social inclusion through adapted physical activity: an action research on the psychological experiences of students, teachers, and corporate volunteers. [PDF]

Front Psychol
Bae G.
europepmc   +1 more source