Results 121 to 130 of about 8,552,368 (315)

Systemic pedagogy: A design for Action Researcher collective self-development

open access: yes, 2015
How do Action Researchers, who often work alone, develop their practice? The Conference Intensive (CI) was designed to enable participants to inquire into their own practice, and observe and learn with a team of Action Researchers negotiating practice ...
Vaartjes, Vicki   +3 more
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Divine Simplicity and the Theory of Action

open access: yesTheoLogica
The modal collapse argument states that the traditional doctrine of divine simplicity entails that God necessarily creates whatever he creates and also that all creatures necessarily perform whatever actions they perform. In response to these objections,
Clemente Huneeus
doaj   +1 more source

Cuckoo – using action research to record oral history

open access: yes, 2011
Objective: To describe use of the Action Research stages of Planning, Action and Reflection as a valuable framework for an artist when developing new work. Approach: Artists generally work intuitively in an Action Research model.
Liebzeit, Anna
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Using Action Research in Practice: Project and Knowledge Management Studies

open access: yes, 2017
The aim of this paper is to describe a direct and personal account of the issues and challenges that occurred in three action research projects that were part of a doctoral research programme.
Duffield, Stephen Mark
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Action potentials in vitro: theory and experiment

open access: yesFrontiers in Physics
Action potential generation underlies some of the most consequential dynamical systems on Earth, from brains to hearts. It is therefore interesting to develop synthetic cell-free systems, based on the same molecular mechanisms, which may allow for the ...
Ziqi Pi, Giovanni Zocchi
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

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