Results 221 to 230 of about 2,728,969 (283)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Structural requirements for intelligent clinical digital twins in feedback-driven care. [PDF]

Npj Health Syst
Wang Y, Smith GE, Lipori GP, Sun RC, Shenkman EA, Liu M, Wu Y, Guo Y.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Semiotic Cultural Psychology Analysis of Musical Improvisation: Creativity as an Affective-Sociocultural Act. [PDF]

Integr Psychol Behav Sci
Monzo D, Glăveanu VP.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Integrated work processes between community health workers and vector control agents: a scoping review. [PDF]

Rev Bras Enferm
Silva KSD, Komori NM, Delfino FAP, Moreira KCC, Goulart BF.   +4 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Touch Restriction Versus Free-Play Small-Sided Games in Soccer: Acute Effects on Serum BDNF, Executive Function, and Technical Actions. [PDF]

Eur J Sport Sci
Birinci YZ, Pancar S, Soylu Y, Sarandöl E, Şimşek H, Şahin Ş, Rumpf MC.   +6 more
europepmc   +1 more source

Deceptive actions in combat sports: an antagonistic decision-making perspective from the lens of "<i>Shi</i>". [PDF]

Front Psychol
Wenfu Z.
europepmc   +1 more source

Strengthening District- and Regional-Level Supportive Supervision for Facility HMIS Data Quality and Data Use in Somalia: A Healthcare Leadership Commentary. [PDF]

J Healthc Leadersh
Osman NH, Mohamed DO, Hussein AM, Sheikh Ali LA, Mohamed FA, Omar MH, Roble AM, Abdi AM, Omar AA, Adam AA.   +9 more
europepmc   +1 more source