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Discriminating activating, deactivating and resistance variants in protein kinases [PDF]

open access: yesGenome Medicine
Background Distinguishing whether genetic variants in protein kinases cause gain or loss of function is critical in clinical genetics. In particular, gain (and not loss)-of-function variants are often immediately amenable to treatment by inhibitors ...
Gurdeep Singh   +10 more
doaj   +2 more sources

Das Erleben der Langeweile und der Aktivierungsprozess der Kinder im frühschulischen DaF-Unterricht [PDF]

open access: yesLinguistische Treffen in Wrocław, 2021
Curiosity and thirst for knowledge are characteristic features of children, which manifest themselves in the fact that an infinite number of questions are asked.
Louise van Wijgerden
doaj   +1 more source

Metoda „pro-kontra” w edukacji ustawicznej [PDF]

open access: yesEdukacja Ustawiczna Dorosłych, 2020
W artykule przedstawiono znaczenie, rodowód, specyfikę oraz przebieg metody pro-kontra. Rozważania teoretyczne uzupełnia opis zajęć z wykorzystaniem metody „pro-kontra” oraz przebieg i wyniki badania jej przydatności w kształceniu ustawicznym.
Aleksander Marszałek
doaj   +1 more source

Future-oriented Innovative Practices for Human Resources Development [PDF]

open access: yesEdukacja Ustawiczna Dorosłych, 2023
Dynamic changes taking place on the labour market justify the need for constant development of competences. Competences necessary in the future will comprise two categories: STEM (Science, Technology, Engineering, and Maths) and soft competences (e.g ...
Beata Poteralska
doaj   +1 more source

Narrative Review on Methods of Activating Irrigation Liquids for Root Canal Treatment

open access: yesApplied Sciences, 2023
As indicated by standards of modern dentistry, the essence of endodontic treatment is chemo-mechanical disinfection of the root canal system. The vital element of this process is the irrigation of canals with designated solutions as well as activating ...
Martyna Raducka   +7 more
doaj   +1 more source

Promoting the construction of intelligent knowledge with the help of various methods of cognitively activating instruction

open access: yesFrontiers in Education, 2023
How can we promote the construction of intelligent knowledge that facilitates the transfer of knowledge to new situations? This article gives an overview of the current state of empirical research on methods of cognitively activating teaching that ...
Ralph Schumacher, Elsbeth Stern
doaj   +1 more source

How Active is Active Learning: Value Function Method Versus an Approximation Method [PDF]

open access: yesComputational Economics, 2020
AbstractIn a previous paper Amman et al. (Macroecon Dyn, 2018) compare the two dominant approaches for solving models with optimal experimentation (also called active learning), i.e. the value function and the approximation method. By using the same model and dataset as in Beck and Wieland (J Econ Dyn Control 26:1359–1377, 2002), they find that the ...
Amman, Hans M., Tucci, Marco P.
openaire   +6 more sources

THE IMPACT OF SUSTAINABLE FURNITURE DESIGN METHODS ON activating THE DURABLE CYCLE OF FURNITURE

open access: yesJournal of Architecture, Art & Humanistic Science, 2021
In light of the economic crises, the prices of furniture industry have increased tremendously beyond the purchase ability of Egyptian consumer, due to the increase of imported raw materials prices entirely which is specified for furniture industry in ...
Samah Abd El-reham   +2 more
doaj   +1 more source

Prediction and classification for GPCR sequences based on ligand specific features [PDF]

open access: yes, 2006
Functional identification of G-Protein Coupled Receptors (GPCRs) is one of the current focus areas of pharmaceutical research. Although thousands of GPCR sequences are known, many of them are orphan sequences (the activating ligand is unknown). Therefore,
F. Horn   +8 more
core   +1 more source

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