Granulocyte-activating mediators (GRAM) [PDF]
, 1988 In the present study we investigated the capability of human epidermal cells to generate granulocyte-activating mediators (GRAM). It could be shown that human epidermal cells as well as an epidermoid carcinoma cell line (A431) produce an epidermal cell ...
Kapp, A. +3 more
core +1 more source
Deficiency of activating Fcγ-receptors reduces hepatic clearance and deposition of IC and increases CIC levels in mercury-induced autoimmunity. [PDF]
PLoS ONE, 2010 BACKGROUND: Inorganic mercury (Hg) induces a T-cell dependent, systemic autoimmune condition (HgIA) where activating Fcγ-receptors (FcγRs) are important for the induction.
Klara Martinsson +5 more
doaj +1 more source
Lattice Boltzmann methods and active fluids [PDF]
The European Physical Journal E, 2019 We review the state of the art of active fluids with particular attention to hydrodynamic continuous models and to the use of Lattice Boltzmann Methods (LBM) in this field. We present the thermodynamics of active fluids, in terms of liquid crystals modelling adapted to describe large-scale organization of active systems, as well as other effective ...
Carenza LN +4 more
openaire +4 more sources
A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]
, 2016 mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat +10 more
core +1 more source
A homolog of the vertebrate pituitary adenylate cyclase-activating polypeptide is both necessary and instructive for the rapid formation of associative memory in an invertebrate [PDF]
, 2010 Similar to other invertebrate and vertebrate animals, cAMP dependent signaling cascades are key components of long-term memory (LTM) formation in the snail Lymnaea stagnalis, an established experimental model for studying evolutionarily conserved ...
Kemenes, György +5 more
core +1 more source
E-cadherin can limit the transforming properties of activating β-catenin mutations [PDF]
, 2015 Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating ...
Alan R Clarke +27 more
core +2 more sources
The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]
, 2017 Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core +2 more sources
The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. [PDF]
, 2012 BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease.
Fehrenbach, Melane L +8 more
core +2 more sources
The dynamics of genome replication using deep sequencing [PDF]
, 2013 Peer reviewedPublisher ...
Agier +64 more
core +3 more sources
ACTIVITY DELAY QUANTUM METHOD (ADQM). [PDF]
International Journal of Advanced Research, 2018 The number of construction disputes are on the rise, especially that nowadays hardly any project completes on its originally agreed contractual completion date. It is noted however, that despite many advances in the ways and techniques by which delays can be assessed and ascertained, the current methods of delay analysis fall short from providing a ...
openaire +1 more source