Results 161 to 170 of about 4,686,218 (315)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Zero-Inflated Promotion Cure-Rate Models With Frailty and Flexible Activation Schemes. [PDF]

Biom J
Assunção D, Ramos PL, Tomazella V, Leão J, Osses L, Rodrigues A.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exploring CRISPR-Mediated Activation of Lineage-Specific Genes for Direct Cellular Reprogramming Using RNPs

openDNA- and Virus-free activation of pluripotency networks offers potential for regenerative medicine and cellular engineering. In this study, a ribonucleoprotein (dRNP)-based CRISPR activation (CRISPRa) system was used to transiently upregulate ...
DORDEVIC, OGNJEN
core  

Dioxygen activation and homogeneous catalytic oxidation proceedings of the Fourth International Symposium on Dioxygen Activation and Homogeneous Catalytic Oxidation

, 1991
Dioxygen activation is a rapidly developing field in which research is directed at (1) modelling of biological oxidations, (2) design and utilization of new catalysts for oxidative transformations of organic substrates, (3) application of O₂ (and H₂O₂ ...
Simándi, L. I. 1935-, International Symposium on Dioxygen Activation and Homogeneous Catalytic Oxidation < 1990, Balatonfüred, Hungary>   +1 more
core  

Is there an alternative to grant-funding for sexual and reproductive health advocacy? A survey of the income base of AmplifyChange grantees

Sexual and Reproductive Health Matters, 2023
Alex le May, Lucie Hazelgrove-Planel
doaj   +1 more source

E3 Ubiquitin Ligases in MASH-Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities. [PDF]

Liver Int
Oh AR, Jeong Y, Jung YH, Kim YU, Gi H, Kim DW, Choi YD, Lee SB, Kim K.   +8 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Heterovalent Metal Pair Sites on Metal–Organic Framework Ordered Macropores for Multimolecular Co-Activation

The precise design of catalytic metal centers with multiple chemical states to facilitate sophisticated reactions involving multimolecular activation is highly desirable but challenging. Herein, we report an ordered macroporous catalyst with heterovalent
Nana Ma (466985), Ming Wang (172316), Zhong Zhang (103242), Yameng Li (1916998), Yiwei Liu (1307874), Wei Liu (20030), Xujiao Ma (11388513), Jiahui Peng (2068402), Yadong Li (317794)   +8 more
core   +1 more source