Results 191 to 200 of about 7,197,000 (313)

Spatial control of NLRP3 inflammasome assembly by membrane lipid composition. [PDF]

Commun Biol
Anand PK, Aljadeed NM.
europepmc   +1 more source

Macrophage activation and polarization.

Frontiers in Bioscience, 2008
F. Martínez, A. Sica, A. Mantovani, M. Locati   +3 more
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.

EMBO Journal, 1991
R. Schreck, Peter Rieberl, P. Baeuerle
semanticscholar   +1 more source

STUDIES ON THE ACTIVATION OF CATALASE ACTIVITY

The Japanese Medical Journal, 1948
openaire   +3 more sources

Detecting Activities

Journal of Visual Communication and Image Representation, 1994
Ramprasad Polana, Randal C. Nelson
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Functional conservation with mechanistic drift: AMP activation in the evolution of archaeal sugar kinases. [PDF]

Mol Biol Evol
M Herrera S, Vallejos-Baccelliere G, Malavé D, Hernández-Cabello L, Castro-Fernandez V, Guixé V.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Refining Left Bundle Branch Block Activation Criteria in CRT Candidates: A Noninvasive Electrocardiographic Imaging Study. [PDF]

Diagnostics (Basel)
Malishevskii L, Zubarev S, Bazhutina A, Markov N, Mikhaylov EN, Chumarnaya T, Stepanova V, Lebedeva V, Solovyova O, Lebedev DS.   +9 more
europepmc   +1 more source