Results 241 to 250 of about 4,686,218 (315)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Perspective on the Development of Monomer Recovery Technologies from Plastics Designed to Last

ACS Organic & Inorganic Au
Steffan K. Kristensen, Alexander Ahrens, Bjarke S. Donslund, Troels Skrydstrup   +3 more
doaj   +1 more source

Decoding fibroblast activation: Transcriptional networks in hepatic stellate cells and across fibrotic organs (Review). [PDF]

Int J Mol Med
Charoenthanakitkul D, Ariyachet C.
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Patient Portal Use and Care Utilization Among Hospitalized Children. [PDF]

Hosp Pediatr
Luke MJ, Zhu Y, Wolk CB, Menko SG, Capriola D, Fuller K, Scribano PV, Bonafide CP, Vasan A.   +8 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

S100 Calcium-Binding Protein 16 (S100A16) Promotes Hepatic Stellate Cell Activation Via Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2)-mediated Glycolysis to Facilitate Liver Fibrosis. [PDF]

Cell Biochem Funct
Ou S, Tang X, Liu J, Ouyang R, Huang S, Weng S, Qin J, Liang D, Du L, Li Z.   +9 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Neural Markers of Reward Valuation and Impulsive Decision-Making in Mania Risk.

JAMA Psychiatry
Raeder R, Arora M, Jones N, Chase HW, Bertocci M, Roberts LT, Bebko G, Aslam HA, Graur S, Taylor M, Atkinson M, Benjamin O, Wang Y, Stiffler R, Phillips ML.   +14 more
europepmc   +1 more source