Results 201 to 210 of about 3,155,671 (268)

Immune complex handling in transplantation: central roles for complement factor H, animal models, and translational implications. [PDF]

Front Immunol
Quigg RJ, Alexander JJ.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The PERK-GADD45A axis is a key driver of hepatic stellate cell activation. [PDF]

Hepatol Commun
Barupala N, Misra J, Bibian E, Baxter R, Singh V, Xique N, Goins ED, Jackson A, Ebert SM, Adams CM, Maiers JL.   +10 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Spatial control of NLRP3 inflammasome assembly by membrane lipid composition. [PDF]

Commun Biol
Anand PK, Aljadeed NM.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Cyclomulberrin from <i>Morus alba</i> L. exerts antithrombotic effects by modulating platelet activation: an integrated network pharmacology and <i>in vitro</i> study. [PDF]

RSC Adv
Guo Y, He R, Peng J, Yuan S, Ma Y, Li Q.
europepmc   +1 more source

Evidence of APOE4-related brain vulnerabilities in verbal memory systems in midlife women. [PDF]

Alzheimers Dement
Wugalter KA, Thurston RC, Wu M, Aizenstein HJ, Kamboh MI, Karikari TK, Maki PM.   +6 more
europepmc   +1 more source

Functional conservation with mechanistic drift: AMP activation in the evolution of archaeal sugar kinases. [PDF]

Mol Biol Evol
M Herrera S, Vallejos-Baccelliere G, Malavé D, Hernández-Cabello L, Castro-Fernandez V, Guixé V.   +5 more
europepmc   +1 more source