Results 31 to 40 of about 7,197,000 (313)

Not All Immune Checkpoints Are Created Equal

Frontiers in Immunology, 2018
Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory surface receptors that are considered to have potential as targets in ...
Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger   +3 more
doaj   +1 more source

FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab

Frontiers in Immunology, 2023
IntroductionTargeting costimulatory receptors of the tumor necrosis factor receptor (TNFR) superfamily with agonistic antibodies is a promising approach in cancer immuno therapy.
Judith Leitner, Ricarda Egerer, Petra Waidhofer-Söllner, Katharina Grabmeier-Pfistershammer, Peter Steinberger   +4 more
doaj   +1 more source

Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer

Nature Communications, 2022
Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains.
Qu Chen, Rajesh Menon, Lesley J. Calder, Pavel Tolar, Peter B. Rosenthal   +4 more
doaj   +1 more source

Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility

EMBO Molecular Medicine, 2018
Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter, Emmanuel Martin, David Boutboul, Christelle Lenoir, Sabah Boudjemaa, Arnaud Petit, Capucine Picard, Alain Fischer, Guy Leverger, Sylvain Latour   +9 more
doaj   +1 more source

Dinuclear PhosphoiminoBINOL-Pd Container for Malononitrile: Catalytic Asymmetric Double Mannich Reaction for Chiral 1,3-Diamine Synthesis

Scientific Reports, 2018
A phosphoiminoBINOL ligand was designed to form a dinuclear metal complex that could hold a malononitrile molecule. The dinuclear bis(phosphoimino)binaphthoxy-Pd2(OAc)2 complex catalyzed a double Mannich reaction of N-Boc-imines with malononitrile to ...
Takayoshi Arai, Katsuya Sato, Ayu Nakamura, Hiroki Makino, Hyuma Masu   +4 more
doaj   +1 more source

Retrograde and Anterograde Transport of Lat-Vesicles during the Immunological Synapse Formation: Defining the Finely-Tuned Mechanism

Cells, 2021
LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments.
Juan José Saez, Stephanie Dogniaux, Massiullah Shafaq-Zadah, Ludger Johannes, Claire Hivroz, Andrés Ernesto Zucchetti   +5 more
doaj   +1 more source

Interrogating ligand-receptor interactions using highly sensitive cellular biosensors

Nature Communications, 2023
Interactions of membrane-resident proteins are important targets for therapeutic interventions but most methods to study them are either costly, laborious or fail to reflect the physiologic interaction of membrane resident proteins in trans.
Maximilian A. Funk, Judith Leitner, Marlene C. Gerner, Jasmin M. Hammerler, Benjamin Salzer, Manfred Lehner, Claire Battin, Simon Gumpelmair, Karin Stiasny, Katharina Grabmeier-Pfistershammer, Peter Steinberger   +10 more
doaj   +1 more source

Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation

Annual Review of Immunology, 2022
As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic invasions and endogenous cellular damage and responds by forming the NLRP3 inflammasome, a supramolecular complex that activates caspase-1.
Jianing Fu, Hao Wu
semanticscholar   +1 more source

B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments

eLife, 2019
Antibody production depends on B cell internalization and presentation of antigens to helper T cells. To acquire antigens displayed by antigen-presenting cells, B cells form immune synapses and extract antigens by the mechanical activity of the acto ...
Sophie I Roper, Laabiah Wasim, Dessislava Malinova, Michael Way, Susan Cox, Pavel Tolar   +5 more
doaj   +1 more source

The Impact of Knowledge About Business Model Canvas (BMC) on Entrepreneurial Interest of Young Generation in Jabodetabek

Indonesian Journal of Business and Entrepreneurship
This research aims to investigate the influence of Business Model Canvas (BMC) knowledge on entrepreneurial knowledge among young generations in the Jabodetabek region.
Nur Hendrasto, Fauziah Chairiyati, Abdullah Haidar, Evania Herindar, Hafiz Mudassir Rehman   +4 more
doaj   +1 more source