Results 1 to 10 of about 25,893,918 (302)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Activation Likelihood Estimation Neuroimaging Meta-Analysis: a Powerful Tool for Emotion Research

open access: yesPsychology Research and Behavior Management
Tommaso Costa,1,2 Mario Ferraro,1– 3 Jordi Manuello,1,2 Alessia Camasio,2,3 Andrea Nani,2 Lorenzo Mancuso,2 Franco Cauda,1,2 Peter T Fox,4,5 Donato Liloia1,2 1GCS-fMRI, Koelliker Hospital and Department of Psychology, University of Turin, Turin, Italy ...
Costa T   +8 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Altered cerebellar activation patterns in Alzheimer’s disease: An activation likelihood estimation Meta-Analysis

open access: yesNeuroImage: Clinical
The past decade has seen an increased interest in the cerebellum, particularly in non-motor behaviors. Emerging work across model systems and in humans has also implicated the cerebellum in Alzheimer’s Disease (AD) and in mild cognitive impairment (MCI).
Jessica A. Bernard   +8 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

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