Results 41 to 50 of about 2,442,763 (316)

An unexpected twist to the activation of IKKβ:TAK1 primes IKKβ for activation by autophosphorylation [PDF]

, 2014
IKKß {IkB [inhibitor of NF-?B (nuclear factor ?B)] kinase ß} is required to activate the transcription factor NF-?B, but how IKKß itself is activated in vivo is still unclear.
Lawrence, T., Peggie, M. W., Lawrence, Toby, Peggie, Mark W., Clark, Kristopher, Cohen, P., Cohen, Philip; id_orcid, Clark, K., Zhang, Jiazhen, Zhang, J.   +9 more
core   +1 more source

CFTR activity and mitochondrial function

Redox Biology, 2013
Cystic Fibrosis (CF) is a frequent and lethal autosomal recessive disease, caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Before the discovery of the CFTR gene, several hypotheses attempted to explain the etiology of this disease, including the possible role of a chloride channel, diverse ...
Valdivieso, Ángel Gabriel, Santa Coloma, Tomás Antonio   +1 more
openaire   +4 more sources

Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]

Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Hills, Claire E., Bennett, Jeanette, Younis, Mustafa Y. G., Squires, Paul E., Liu, Kuo-Kang, Siamantouras, Eleftherios   +5 more
core   +1 more source

Plantar flexor voluntary activation capacity, strength and function in cerebral palsy

, 2021
Purpose: Distal lower limb motor impairment impacts gait mechanics in individuals with cerebral palsy (CP), however, the contribution of impairments of muscle activation to reduced gross motor function (GMF) is not clear.
Lichtwark, GA, Carroll, TJ, O’Brien, SM, Barber, LA   +3 more
core   +1 more source

Coastline Extraction Method Based on Convolutional Neural Networks—A Case Study of Jiaozhou Bay in Qingdao, China

IEEE Access, 2019
The traditional edge detection-based shoreline extraction method is severely disturbed by noise, and it is difficult to obtain a continuous coastline.
Xiao-Ying Liu, Rui-Sheng Jia, Qing-Ming Liu, Chao-Yue Zhao, Hong-Mei Sun   +4 more
doaj   +1 more source

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation [PDF]

, 2014
The goal of the current work was to profile positive (mTORC1 activation, autocrine/paracrine growth factors) and negative [AMPK, unfolded protein response (UPR)] pathways that might regulate overload-induced mTORC1 activation with the hypothesis that a ...
Hamilton, D. Lee, Gallagher, Iain J, Philp, A., Baar, Keith, Towler, Mhairi C., Bodine, S. C., Gallagher, Iain J., Philp, Andrew, Towler, M. C., Baar, K., Towler, Mhairi C, Mackenzie, M. G., Gallagher, I. J., Patton, Amy, Hamilton, David Lee, Patton, A., MacKenzie, Matthew G., Lee Hamilton, D., Bodine, Sue C, Bodine, Sue C., MacKenzie, Matthew G   +20 more
core   +1 more source

Optimizing Activation Function for Parameter Reduction in CNNs on CIFAR-10 and CINIC-10

Applied Sciences
This paper explores a simple CNN architecture used for image classification. Since the first introduction of the CNN idea, LeNet5, CNNs have become the main method for image exploration.
Vasil Vasilev, Vasil Shterev, Maria Nenova   +2 more
doaj   +1 more source

Hyperspectral Image Denoising With Dual Deep CNN

IEEE Access, 2019
A new hyperspectral image denoising algorithm, called the dual deep convolutional neural network (DD-CNN), is proposed in this paper. In contrast to internal denoising methods that utilize only the features from the target noisy image, the DD-CNN ...
Wei Shan, Peng Liu, Lin Mu, Caihong Cao, Guojin He   +4 more
doaj   +1 more source

Learning Combinations of Activation Functions [PDF]

2018 24th International Conference on Pattern Recognition (ICPR), 2018
In the last decade, an active area of research has been devoted to design novel activation functions that are able to help deep neural networks to converge, obtaining better performance. The training procedure of these architectures usually involves optimization of the weights of their layers only, while non-linearities are generally pre-specified and ...
Franco Manessi, Alessandro Rozza
openaire   +2 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source