Results 81 to 90 of about 2,442,763 (316)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Activation Function: Key to Cloning from Human Learning to Deep Learning

, 2020
Maneuvering a steady on-road obstacle at high speed involves taking multiple decisions in split seconds. An inaccurate decision may result in crash. One of the key decision that needs to be taken is can the on-road steady obstacle be surpassed. The model
Pranit Gopaldas Shah, Hiral Pranit Shah
core  

Dual Role of CREB in The Regulation of VSMC Proliferation: Mode of Activation Determines Pro- or Anti-Mitogenic Function.

, 2018
Vascular smooth muscle cell (VSMC) proliferation has been implicated in the development of restenosis after angioplasty, vein graft intimal thickening and atherogenesis.
Duggirala, A.
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Modulation of NF-kappaB activation in Theileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton [PDF]

, 2010
Apicomplexan parasites within the genus <i>Theileria</i> have the ability to induce continuous proliferation and prevent apoptosis of the infected bovine leukocyte.
Weir, W., Hermann, P., McKellar, S., Dobbelaere, D., Dobbelaere, Dirk,, Schmuckli-Maurer, J., Pillai, S., Shiels, B., Kinnaird, J.   +8 more
core   +1 more source

Influence of activation function on loss function.

, 2023
Influence of activation function on loss function.
Xiaohong Chen (220164), Yueyue Zhang (410441), Pei Ge (740652)   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

INTELLIGENT ROUTING IN THE NETWORK OF INFORMATION AND TELECOMMUNICATION SYSTEM OF RAILWAY TRANSPORT

Nauka ta progres transportu, 2019
Purpose. At the present stage, the strategy of informatization of railway transport of Ukraine envisages the transition to a three-level management structure with the creation of a single information space, therefore one of the key tasks remains the ...
V. M. Pakhomova, T. I. Skaballanovich, V. S. Bondareva   +2 more
doaj   +1 more source

On Polynomial Approximation of Activation Function

CoRR, 2022
In this work, we proposed an interesting method to approximate the activation function by a polynomial the degree of which is preset low. Our method to approximate the activation function is much more flexible compared to the least square method in the sense that the additional parameters could better control the shape of the resulting polynomial to ...
openaire   +2 more sources

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function

, 2014
This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Wang, Jian, Pestell, RG0, Fuqua, Suzanne A W, Wang, Chenguang, Yeung, YG, Hopp, Torsten, Jaffray, E, Chang, Chawnshang, Fu, Maofu, Sakamaki, Toshiyuki, Janne, OA, Zhang, Xueping, Hay, Ronald Thomas, Palvimo, Jorma J   +13 more
core   +1 more source