Results 101 to 110 of about 9,586,286 (339)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

The indirect effect of age group on switch costs via grey matter volume and task-related brain activity

Frontiers in Aging Neuroscience, 2016
Healthy aging simultaneously affects brain structure, brain function and cognition. These effects are often investigated in isolation ignoring any relationships between them.
Jason Steffener, Jason Steffener, Jason Steffener, Yunglin Gazes, Christian Habeck, Yaakov Stern   +5 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Dielectric properties of Granodiorite partially saturated with water and its correlation to the detection of seismic electric signals

, 2011
Transient electric signals emitted prior to earthquake occurrence are recorded at certain sites in the Earth's crust termed sensitive. These field observations enforce the laboratory investigation of the dielectric response of rocks forming these ...
A.N. Papathanassiou, Endres, Fontanella, Fontanella, I. Sakellis, J. Grammatikakis, Morgan, Morgan, Nettelblad, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Surkov, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos   +38 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Molecular Probing of the Stress Activation Volume in Vapor Phase Lubricated Friction. [PDF]

ACS Appl Mater Interfaces, 2023
Hsu CC, Peng L, Hsia FC, Weber B, Bonn D, Brouwer AM.   +5 more
europepmc   +1 more source

The Effects of Weak Spatiotemporal Noise on a Bistable One-Dimensional System

, 2003
We treat analytically a model that captures several features of the phenomenon of spatially inhomogeneous reversal of an order parameter. The model is a classical Ginzburg-Landau field theory restricted to a bounded one-dimensional spatial domain ...
Maier, Robert S., Stein, D. L.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Pressure dependence of the interfacial polarization and negative activation volume for dielectric relaxation in heterogeneous systems

Results in Earth Sciences
Negative activation volumes for dielectric relaxation are rarely reported in solid state physics and are limited to atomic scale processes. Broadband Dielectric Spectroscopy on heterogeneous systems, such as polycrystalline calcite and magnesite, hosting
Anthony N. Papathanassiou
doaj   +1 more source