Results 141 to 150 of about 9,586,286 (339)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Nuclear Engineering and TechnologyKATANA is a water activation facility at the Jožef Stefan Institute TRIGA Mark II reactor in Ljubljana, Slovenia, developed to study water activation processes relevant for future fusion systems such as ITER.
Julijan Peric +4 more
doaj +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
The effect of estradiol add-back: a longitudinal MRI study in prostate cancer patients
Endocrine ConnectionsWe investigated the effect of estradiol add-back therapy (EAT) on brain activation related to cognitive function and affect in addition to putative changes in gray and white matter volume in testosterone depleted participants with prostate cancer.
Orwa Dandash +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Orientation-Independent Yield Stress and Activation Volume of Dislocation Nucleation in LiTaO3 Single Crystal by Nanoindentation. [PDF]
Materials (Basel), 2019 Ma Y +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Cell Volume Regulation in Immune Cell Function, Activation and Survival
Cellular Physiology and Biochemistry, 2021 Matt Como +5 more
doaj +1 more source
Preparation of Nanoporous Adsorbents from Brown Coal Using Alkali Activation and Thermal Shock
Хімія, фізика та технологія поверхні, 2012 Thermal-shock KOH activation has been used to produce nanoporous activated carbon from brown coal. The specific surface area, total pore volume, volumes of micropores and subnanometer pores were determined for activated carbons prepared at a varied ...
Yu. V. Tamarkina +4 more
doaj