Results 181 to 190 of about 80,800 (296)

Severe Hyponatremia From Lupus-Related Syndrome of Inappropriate Antidiuresis (SIADH): A Diagnostic Challenge. [PDF]

Cureus
Alrashidi FS.
europepmc   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

The A, B, C, D's of replicative DNA polymerase fidelity: utilizing high-throughput single-molecule sequencing to understand the molecular basis for DNA polymerase accuracy. [PDF]

Nucleic Acids Res
Betancurt-Anzola L, O'Connell KC, Potapov V, Ong JL, Tanner NA, Sauguet L, Zatopek KM.   +6 more
europepmc   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

Reassessing the Conduct of Patch Clamp Cardiac Ion Channel Assays to Improve Nonclinical Data Translation to Clinical ECG Changes and Proarrythmia Risk. [PDF]

Clin Transl Sci
Alvarez Baron C, Zhao J, Guo D, Mistry S, De Palma R, Ismaiel OA, Wu WW.   +6 more
europepmc   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference. [PDF]

Nat Commun
Hvorecny KL, Interlandi G, Veth TS, Aprikian P, Manchenko A, Tchesnokova VL, Dickinson MS, Quispe JD, Riley NM, Klevit RE, Magala P, Sokurenko EV, Kollman JM.   +12 more
europepmc   +1 more source

Enhancing the Ultrasonic Welding of Wood Using 3D Printed Lignin Energy Directors

Advanced Science, EarlyView.
Sustainable manufacturing for lightweight structures using ecofriendly materials will be key to reducing material consumption and lowering carbon footprints. Here, an approach is presented to weld wood using ultrasonic vibrations with material at the joint interface to direct energy.
Muhamad Amani, Kathrin Weiland, Mark Ablonczy, Natalia Sofia Guevara‐Sotelo, Ioannis Zygouris, Johan van Stuyvesant Meijen, Kunal Masania   +6 more
wiley   +1 more source

Stress-Induced Reorganization of Proteasomes Through Diffusion and Cytoskeleton-Dependent Mechanisms. [PDF]

Small
Morten MJ, Zhang Y, Li B, Meng JX, Jiang K, Sirvio L, Lee JE, Lippert AH, Burridge M, Pulgar Prieto KD, Carr AR, Ponjavic A, Lee SF, Finley D, Klenerman D, Ye Y.   +15 more
europepmc   +1 more source

Dual-Input Isolated Full-Bridge Boost DC-DC Converter Based on the Distributed Transformers [PDF]

, 2012
Andersen, Michael A. E., Nielsen, Henning R., Thomsen, Ole Cornelius, Zhang, Zhe   +3 more
core   +1 more source