Results 31 to 40 of about 3,292,938 (307)

A Soft-Switching High-Gain DC–DC Converter Employing an Active-Clamp Circuit

IEEE Access
A soft-switching high step-up DC–DC converter based on the coordinated integration of an input inductor, a three-winding coupled inductor, a switched-capacitor voltage multiplier, and an active-clamp circuit is developed in this work. High voltage
Thai Anh Au Tran, Xuan Khanh Ho
doaj   +1 more source

Autism-associated mutations in the CaVβ2 calcium-channel subunit increase Ba2+-currents and lead to differential modulation by the RGK-protein Gem

Neurobiology of Disease, 2020
Voltage-gated calcium-channels (VGCCs) are heteromers consisting of several subunits. Mutations in the genes coding for VGCC subunits have been reported to be associated with autism spectrum disorder (ASD).
Patrick Despang, Sarah Salamon, Alexandra F. Breitenkamp, Elza Kuzmenkina, Stefan Herzig, Jan Matthes   +5 more
doaj   +1 more source

The Effects of Acute High‐Intensity Interval Exercise and Hyperinsulinemic‐Euglycemic Clamp on Osteoglycin Levels in Young and Middle‐Aged Men

JBMR Plus, 2022
Osteoglycin (OGN) is a leucine‐rich proteoglycan that has been implicated in the regulation of glucose in animal models. However, its relationship with glucose control in humans is unclear. We examined the effect of high‐intensity interval exercise (HIIE)
Carlie Bauer, Alexander Tacey, Andrew Garnham, Cassandra Smith, Mary N Woessner, Xuzhu Lin, Navabeh Zarekookandeh, David L Hare, Joshua R Lewis, Lewan Parker, Itamar Levinger   +10 more
doaj   +1 more source

Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes [PDF]

, 2012
Background and aim: Human atrial transient outward K+ current (ITO) is decreased in a variety of cardiac pathologies, but how ITO reduction alters action potentials (AP) and arrhythmia mechanisms is poorly understood, owing to non-selectivity of ITO ...
Marshall, G.E., Dempster, J., Smith, G.L., Rankin, A.C., Workman, A.J.   +4 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Performance comparison and analysis of quasi resonant and active clamp flyback converters

Dianzi Jishu Yingyong
High frequency, high efficiency, and high power density have become important design indicators for AC-DC converters. Traditional quasi resonant flyback converters, due to their reliance on passive resistive components to release leakage energy in the ...
Liu Zhibin, Pan Yongxiong, Wu Jianhong
doaj   +1 more source

Classical and numerical approaches to determining V-section band clamp axial stiffness [PDF]

, 2014
V-band clamp joints are used in a wide range of applications to connect circular flanges, for ducts, pipes and the turbocharger housing. Previous studies and research on V-bands are either purely empirical or analytical with limited applicability on the ...
Khodabakhshi, Goodarz, Barrans, Simon, Muller, Matthias, Khodabakhshi Goodarz, Barrans, Simon M., Muller Matthias, Barrans Simon M.   +6 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Origin of the Phosphoprotein Phosphatase (PPP) sequence family in Bacteria: Critical ancestral sequence changes, radiation patterns and substrate binding features

BBA Advances, 2021
Background: Phosphoprotein phosphatases (PPP) belong to the PPP Sequence family, which in turn belongs to the broader metallophosphoesterase (MPE) superfamily.
David Kerk, Mario E. Valdés-Tresanco, Ryan Toth, Sergei Yu. Noskov, Kenneth K.-S. Ng, Greg B. Moorhead   +5 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source