Results 141 to 150 of about 82,647 (261)

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

The RecBCD complex interacts directly with the DNA sliding clamp in Escherichia coli. [PDF]

Nucleic Acids Res
Riisnæs IMM, Ræder SB, Simonsen S, Vikedal K, Backe PH, Johnsen L, Bjørås M, Booth JA, Kragelund BB, Skarstad K, Helgesen E.   +10 more
europepmc   +1 more source

Rod Origami (RodOri) Spring Metamaterials for Tunable Vibration Control via Tailored Structural Instabilities

Advanced Science, EarlyView.
Rod Origami (RodOri) springs harness snap‐through instabilities of pre‐stressed curved rods with geometrically programmable buckling behavior. Integrating RodOri springs with distinct geometries yields multistable metamaterials that undergo stepwise reconfiguration via sequential snapping, achieving wide‐range tunability of stiffness and resonance ...
Jeseung Lee, Sophie Leanza, Ruike Renee Zhao   +2 more
wiley   +1 more source

A novel ψ-χ fusion protein for unravelling the contributions of χ to DNA replication and repair. [PDF]

Nucleic Acids Res
Padgett-Pagliai KA, Wimer E, Grant JD, Petrides MJ, Newcomb ESP, Sutera VA, Lovett ST, Bloom LB.   +7 more
europepmc   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Structural and evolutionary dissection of NADPH-binding motifs in NADPH-preferring ene-reductases. [PDF]

Protein Sci
Kerschbaumer B, Frießer EM, Wallner S, Oberdorfer G, Friess M, Breinbauer R, Macheroux P, Bijelic A.   +7 more
europepmc   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Galanin Inhibits Histaminergic Neurons via Galanin Receptor 1. [PDF]

eNeuro
Khouma A, Chabot-Chartier A, Plamondon J, Caron A, Michael NJ.   +4 more
europepmc   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Methods for tagging whale sharks: insights into performance and best practices with a focus on clamp attachments. [PDF]

Anim Biotelemetry
Womersley FC, Green S, Garcia-Baciero A, Conlon R, Jeffries AL, Waller MJ, Ratão SS, Queiroz N, Afonso P, Araujo G, Barnett A, Barry C, Berumen ML, Bloch F, Boldrocchi G, Braun CD, Caillouet R, Chapman C, Cochran JEM, de la Parra R, Diamant S, Dove ADM, Dunbabin M, Erdmann MV, Ferreira LC, Fitzpatrick R, Fontes J, Gleiss AC, Green JR, Griffin LP, Griffin CR, Hardenstine RS, Hassan A, Hearn AR, Hendon JM, Putra MIH, Hoffmayer E, Hoopes L, Hueter RE, John S, Levenson J, Lewis S, Macena BCL, Meekan MG, Miller IB, Norman B, Paulsen J, Perry C, Pierce SJ, Reynolds SD, Robinson DP, Rohner CA, Schmidt J, Setyawan E, Sianipar AB, Smith J, Thorrold SR, Thums M, Wilson R, Southall EJ, Sims DW.   +60 more
europepmc   +1 more source