Results 71 to 80 of about 4,534,827 (376)

3D‐Printed Serial Snap‐Through Architectures for Programmable Mechanical Response

Advanced Engineering Materials, EarlyView.
A serial snap‐through architecture is realized using compact 3D‐printed von Mises truss units arranged in a staged cascade. Their geometry and boundary conditions program multistage mechanical responses with plateaux and re‐hardening regimes. An inverted‐compliance model predicts these behaviors and enables analytical design of programmable force ...
Filipe A. Santos
wiley   +1 more source

Slowly cycling Rho kinase-dependent actomyosin cross-bridge slippage explains intrinsic high compliance of detrusor smooth muscle [PDF]

, 2017
Biological soft tissues are viscoelastic because they display timeindependent pseudoelasticity and time-dependent viscosity. However, there is evidence that the bladder may also display plasticity, defined as an increase in strain that is unrecoverable ...
Hurley, Tanner, Klausner, Adam P., Lin, Jia B., Miner, Amy S., Neal, Christopher J., Ratz, Paul H., Speich, John E.   +6 more
core   +2 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Transcription initiation at a consensus bacterial promoter proceeds via a ‘bind-unwind-load-and-lock’ mechanism

eLife, 2021
Transcription initiation starts with unwinding of promoter DNA by RNA polymerase (RNAP) to form a catalytically competent RNAP-promoter complex (RPo). Despite extensive study, the mechanism of promoter unwinding has remained unclear, in part due to the ...
Abhishek Mazumder, Richard H Ebright, Achillefs N Kapanidis   +2 more
doaj   +1 more source

Interleaved Active-Clamping Converter With ZVS/ZCS Features

IEEE Transactions on Power Electronics, 2010
In this paper, an interleaved soft-switching dc-to-dc converter configuration is proposed. It consists of two parts: the primary side is a constant-frequency asymmetrical converter with active-clamp feature and the secondary side is a series-resonant tank circuit.
Hsia, Tsun-Hsiao, Tsai, Hsien-Yi, Chen, Dan, Lee, Martin, Huang, Chun-Shih   +4 more
openaire   +2 more sources

Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]

, 2013
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Kauferstein, Silke, Kendel, Yvonne, Kurz, Alexander, Mebs, Dietrich, Melaun, Christian, Nicke, Annette, Peigneur, Steve, Tytgat, Jan, Wunder, Cora   +8 more
core   +3 more sources

Photocatalytic Versus Stoichiometric Hydrogen Generation Using Mesoporous Silicon Catalysts: The Complex Role of Sacrificial Reagents

Advanced Functional Materials, EarlyView.
This study highlights the importance of accounting for stoichiometric hydrogen produced when utilizing Si photocatalysts. The stoichiometric contribution is sacrificial reagent dependent and decreases with increasing sterics around the catalyst surface.
Sarrah H. Putwa, Sarah A. Martell, Berthold Reis, Simona Schwarz, Mita Dasog   +4 more
wiley   +1 more source

Active-Clamp Dual-Transformer ZVS Flyback Converter

Energies
In order to upgrade the ability of the traditional flyback converter to transfer energy to the load, a dual-flyback converter with two active clamping circuits is added, using the same clamping capacitor to recover the leakage inductance energy ...
Pei-Ching Tseng, Kuo-Ing Hwu, Yu-Lin Chen, Jenn-Jong Shieh   +3 more
doaj   +1 more source

Patterning the Void: Combining L‐Systems with Archimedean Tessellations as a Perspective for Tissue Engineering Scaffolds

Advanced Functional Materials, EarlyView.
This study introduces a novel multi‐scale scaffold design using L‐fractals arranged in Archimedean tessellations for tissue regeneration. Despite similar porosity, tiles display vastly different tensile responses (1–100 MPa) and deformation modes. In vitro experiments with hMSCs show geometry‐dependent growth and activity. Over 55 000 tile combinations
Maria Kalogeropoulou, Kenny A. van Kampen, Pierpaolo Fucile, Carlos Mota, Lorenzo Moroni   +4 more
wiley   +1 more source

Electrophysiological Properties of Neurons: Current-Clamp Recordings in Mouse Brain Slices and Firing-Pattern Analysis

Bio-Protocol, 2021
Characterization of an electrically active cell, such as a neuron, demands measurement of its electrical properties. Due to differences in gene activation, location, innervation patterns, and functions, the millions of neurons in the mammalian brain are ...
Elina Nagaeva, Ivan Zubarev, Esa Korpi
doaj   +1 more source