Results 171 to 180 of about 7,560,096 (305)

Traffic signal active control method for short-distance intersections. [PDF]

PLoS One
Tian Y, Liu S, Wei L, Li Z, Tang S, Zhang Y, Zhu T.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Active control over exploration improves memory in toddlers. [PDF]

Proc Biol Sci
Li YL, Poli F, Ruggeri A.
europepmc   +1 more source

Interpretation of active-control randomised trials: the case for a new analytical perspective involving averted events. [PDF]

BMC Med Res Methodol, 2023
Dunn DT, Stirrup OT, McCormack S, Glidden DV.   +3 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A single-blind active-control randomized controlled trial of group-based social competence intervention. [PDF]

Sci Rep
Kang E, Rosen TE, Keifer CM, Gerber AH, Lerner MD.   +4 more
europepmc   +1 more source

Active control of dielectric singularities in indium-tin-oxides hyperbolic metamaterials. [PDF]

Sci Rep, 2022
Pianelli A, Caligiuri V, Dudek M, Kowerdziej R, Chodorow U, Sielezin K, De Luca A, Caputo R, Parka J.   +8 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Active control of excitonic strong coupling and electroluminescence in electrically driven plasmonic nanocavities. [PDF]

Sci Adv
Zheng J, Krasavin AV, Yang R, Wang Z, Feng Y, Tang L, Li L, Guo X, Dai D, Zayats AV, Tong L, Wang P.   +11 more
europepmc   +1 more source

Taurolidine/Heparin Lock Solution and Catheter-Related Bloodstream Infection in Hemodialysis: A Randomized, Double-Blind, Active-Control, Phase 3 Study. [PDF]

Clin J Am Soc Nephrol, 2023
Agarwal AK, Roy-Chaudhury P, Mounts P, Hurlburt E, Pfaffle A, Poggio EC.   +5 more
europepmc   +1 more source