Results 221 to 230 of about 3,470,000 (296)

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

A Smart Fluid-Hydraulic System Based on MRF Valve Control and Its Application in Flexible Grasping. [PDF]

Adv Sci (Weinh)
Huo L, Ji H, Hong R, Nie S, Yin F, Ma Z.
europepmc   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Broadband and wide-temperature dissipation continuum in a supramolecular damping organohydrogel for motion-tolerant bioelectronics. [PDF]

Nat Commun
Zhou N, Liu S, Lei Z, Wu P.
europepmc   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

A theoretical description of the tree cricket ear as a highly phase sensitive biomechanical interferometer. [PDF]

iScience
Celiker E, Sutton GP, Mhatre N.
europepmc   +1 more source

Domain knowledge-integrated reinforcement learning control of nonlinear tunable vibration absorber under nonstationary excitation. [PDF]

Sci Rep
Park JE, Kang H, Kim YK.
europepmc   +1 more source

Active Pitch Stabilization of Tracked Platforms Using a Nonlinear Dynamic Model for Coordinated Inertial Actuation. [PDF]

Sensors (Basel)
Fazylova A, Alipbayev K, Nogaibayeva M, Iliev T, Stoyanov I.   +4 more
europepmc   +1 more source

A Personalized Gait Parameter Prediction-Based Speed-Adaptive Control Method for Hybrid Active-Passive Intelligent Prosthetic Knee. [PDF]

Biomimetics (Basel)
Wang X, Li Y, Li H, Luo S, Yu H.
europepmc   +1 more source

Development of an active damping device

, 2022
openaire   +1 more source