Results 141 to 150 of about 2,126,817 (301)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Thermally Aware Design of Large-Format Batteries Driven by an Equivalent Circuit Network-Based Electro-Thermal Model

Batteries
Large-format pouch cells enable higher pack-level energy density and simplified system architecture, yet they pose significant thermal challenges due to long internal conduction paths, pronounced spatial gradients, and limited access to core temperature.
Junlong Niu, Hua Tang, Hongwei Li, Caiping Zhang, Linjing Zhang, Bingxiang Sun, Kai Gao, Tong Li, Tao Zhu   +8 more
doaj   +1 more source

The interconnection in active distribution networks

, 2008
The active distribution network (AN) has been mentioned recently to adapt with a large-scale implementation of distributed generators. One of its enhancements is increasing interconnections to provide more than one power flow path among local control areas.
Nguyen, H.P., Myrzik, J.M.A., Kling, W.L.   +2 more
openaire   +1 more source

Active Distribution Networks Operation Within a Distribution Market Environment

, 2017
No This chapter proposes a novel method for the operation of active distribution networks within a distribution market environment taking into account multi-configuration of wind turbines. Multi-configuration multi-scenario market-based optimal power flow is used to maximise the social welfare considering uncertainties related to wind speed and load ...
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Investigation of energy storage batteries in stability enforcement of low inertia active distribution network [PDF]

, 2019
AK Srivastava, Andreas Ulbig, D Naimi, DM Greenwood, F Selwa, H Markiewicz, J Alipoor, JM Morales, K Heising, KI Jennett, M Patel, M Reza, N Pogaku, N Soni, P Kundur, P Kundur, PT Manditereza, R Sebastián, S Ayasun, S Eftekharnejad, SK Salman, T Sun, TS Ustun, Y Bian, Y Shi   +24 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source