Results 91 to 100 of about 4,313,187 (347)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Directed Ligand Passage Over the Surface of Diffusion-Controlled Enzymes: A Cellular Automata Model

, 2004
The rate-limiting step of some enzymatic reactions is a physical step, i.e. diffusion. The efficiency of such reactions can be improved through an increase in the arrival rate of the substrate molecules, e.g.
Ghaemi, Mehrdad, Rezaei-Ghaleh, Nasrollah, Sarbolouki, Mohammad-Nabi   +2 more
core   +1 more source

Coordination of network reconfiguration and mobile energy storage system fleets to facilitate active distribution network restoration under forecast uncertainty [PDF]

, 2023
Yundai Xu, Min Zhao, Han Wu, Sheng Xiang, Yue Yuan   +4 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Integrating active demand into the distribution system using metaheuristic techniques

The Journal of Engineering
Integrating non‐conventional renewable energy sources into distribution systems, alongside data science and enabling technological infrastructures, presents significant challenges, particularly in managing active demand.
Edgar Dario Obando‐Paredes, Dahiana López‐García, Sandra X. Carvajal‐Quintero   +2 more
doaj   +1 more source

Market Equilibrium in Active Distribution System With $\mu $ VPPs: A Coevolutionary Approach

IEEE Access, 2017
To further liberalize the retail electricity market, this paper establishes a novel active distribution system market (ADSM) to encourage the new entries of micro virtual power plants (μVPPs) as prosumers.
Hao Fu, Xiao-Ping Zhang
doaj   +1 more source

Free-running InGaAs single photon detector with 1 dark count per second at 10% efficiency

, 2014
We present a free-running single photon detector for telecom wavelengths based on a negative feedback avalanche photodiode (NFAD). A dark count rate as low as 1 cps was obtained at a detection efficiency of 10%, with an afterpulse probability of 2.2% for
Gisin, Nicolas, Korzh, Boris, Lunghi, Tommaso, Walenta, Nino, Zbinden, Hugo   +4 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Complete active-reactive power resource scheduling of smart distribution system with high penetration of distributed energy resources

Journal of Modern Power Systems and Clean Energy, 2017
In traditional power systems, besides the conventional power plants that provide the necessary reactive power in transmission system, the shunt capacitors along with the tap changers of transformers are also employed in distribution networks.
Abouzar SAMIMI, Mehdi NIKZAD
doaj   +1 more source