Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Active Distribution Network Modeling for Enhancing Sustainable Power System Performance; a Case Study in Egypt [PDF]
, 2020 Ali Radwan +4 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
MDP based real time restoration for earthquake damaged active distribution systems
, 2023 Onur Yigit Arpali +4 more
openalex +2 more sources
A Procedure to Determine the Droop Constants of Voltage Controllers Coping with Multiple DG Interactions in Active Distribution Systems [PDF]
, 2020 Giuseppe Fusco, Mario Russo
openalex +1 more source
Operational strategy optimisation of VRB energy storage systems considering the dynamic characteristics of VRB in active distribution networks [PDF]
, 2021 Jiazhi Lei, Wenzhong Gao, Jinhong Liu
openalex +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Bi-level coordinated operation strategy of an active distribution system with load aggregators
International Journal of Electrical Power & Energy SystemsLoad aggregator (LA) is an effective form of managing multiple distributed energy sources on the user side. With the increase of emerging market players such as LAs, it is of great significance to realize the coordinated optimization of multiple entities
Mengjun Shen +2 more
doaj +1 more source