Results 61 to 70 of about 3,734,613 (296)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Active fault-tolerant control and performance simulation of electric vehicle suspension based on improved algorithms

EAI Endorsed Transactions on Energy Web
Based on the semi-active suspension controller of an automobile, the control law can be adjusted based on the control law reorganization idea, and the active fault-tolerant controller of the semi-active suspension is designed to make the fault closed ...
Caiyuan Xiao
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Preliminary study on the Late Quaternary activity of important active fault zones along the Yunnan-Tibet railway

地震科学进展
The Yunnan-Tibet railway is located in the southeastern edge of the Tibetan Plateau, where tectonic plates collide and the terrain rapidly changes. Along the line, active faults develops, earthquakes occur frequently, and the intensity of earthquakes is ...
Xianbing Zhang, Hao Yu, Xiao Yu, Changbao Guo, Rui’an Wu, Yang Wang, Ning Zhong   +6 more
doaj   +1 more source

Adaptive and Robust Fault-Tolerant Tracking Control of Contact force of Pantograph-Catenary for High-Speed Trains [PDF]

, 2015
This paper presents a modified multi-body dynamic model and a linear time-invariant model with actuator faults (loss of effectiveness faults, bias faults) and matched and unmatched uncertainties.
Yan, Xinggang, Zhang, Kang-K, Mao, Zehui, Jiang, Bing   +3 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Palaeoseismologic and geomorphic investigations along the middle portion of the Ovindoli-Pezza Fault (Central Italy)

Annals of Geophysics, 1996
his paper presents the results of a detailed investigation performed along the central part of the Ovindoli- Pezza Fault with the aim of improving our understanding of the seismic behaviour of this fault within Central Italy seismogenesis. Results of the
P. M. De Martini, D. Pantosti, G. D' Addezio   +2 more
doaj   +1 more source

The late Quaternary slip-rate of the Har-Us-Nuur fault (Mongolian Altai) from cosmogenic Be-10 and luminescence dating [PDF]

, 2009
The Altai range (western Mongolia) accommodates NNE–SSW shortening across the northern India–Eurasia collision zone by dextral slip on faults trending NNW–SSE, and anticlockwise, vertical-axis rotations of fault-bounded blocks.
Bayasgalan, A., Walker, R. T., West, A.J., Amgalan Bayasgalan, Erdenebat Molor, Molor, E., Andrew Carter, Carter, A., Nissen, E., Bayasgalan, A.., Xu, S., Schnabel, C., Carter, Andrew, Fattahi, M., Edwin Nissen, Morteza Fattahi, Christoph Schnabel, Nissen, E. K., A. Joshua West, Richard T. Walker, Sheng Xu, Walker, R.T., West, A. J.   +22 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source