Results 121 to 130 of about 740,418 (299)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Operational Trans-Resistance Amplifier Based Tunable Wave Active Filter [PDF]

open access: yes, 2013
In this paper, Operational Trans-Resistance Amplifier (OTRA) based wave active filter structures are presented. They are flexible and modular, making them suitable to implement higher order filters.
Bothra, M.   +3 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Multiscale Morphological Filtering for Analysis of Noisy and Complex Images [PDF]

open access: yes
Images acquired with passive sensing techniques suffer from illumination variations and poor local contrasts that create major difficulties in interpretation and identification tasks.
Kher, A., Mitra, S.
core   +1 more source

Broad Band Photometric Reverberation Mapping of NGC 4395

open access: yes, 2012
We present results of broad band photometric reverberation mapping (RM) to measure the radius of the broad line region, and subsequently the black hole mass (M$_{\rm BH}$), in the nearby, low luminosity active galactic nuclei (AGN) NGC 4395.
Abazajian   +27 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

0.5 V Digitally-Tunable Filters for Biomedical Applications Exploiting Segmented Duty-Cycled Resistors

open access: yesIEEE Access
In this paper, we present the design and the experimental validation of a biquad filter for biomedical applications that takes advantage of segmented duty-cycled resistors to allow for digital tuning over a wide range of the cutoff frequency ( $f_{0}$ ),
Alessandro Fava   +2 more
doaj   +1 more source

Active filters for power quality improvement [PDF]

open access: yes, 2001
This paper deals with problems related with harmonics in power system networks. Several international standards issued to control power quality problems are briefly described and some important methods to analyse electrical circuits with non-sinusoidal ...
Afonso, João L.   +2 more
core  

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