Results 91 to 100 of about 1,024,804 (310)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Active Aerodynamic Control of a Separated Flow Using Streamwise Synthetic Jets [PDF]

, 2019
LES simulations at Re=1 710^5 and wind tunnel experiments at Re=5 710^5 were con-ducted to investigate the beneficial effect of an active flow control (AFC) technique on theaerodynamic performance of a simplified truck geometry.
Basara, Branislav, Basara, Branislav,, Chernoray, Valery,, Krajnovic, Sinisa, Tokarev, Mikhail,, Zhang, Jie,, Minelli, Guglielmo, Liu, Tanghong, Krajnovic, Sinisa,, Tokarev, Mikhail, Zhang, Jie, Minelli, Guglielmo,, Liu, Tanghong,, Chernoray, Valery   +13 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Integrated aeroelastic and control analysis of wind turbine blades equipped with microtabs [PDF]

, 2015
This paper presents the results of an investigation into the performance of different controllers in active load control of wind turbine blades equipped with microtabs.
Macquart, Terence, Maheri, Alireza
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Active and Passive Flow Control around Simplified Ground Vehicles

Journal of Applied Fluid Mechanics, 2012
The aim of this work is to control the flow around ground vehicles by active or/and passive strategies. The active control is achieved by steady, pulsed or closed-loop jets located at the backof the simplified car model.
C.H Bruneau, E. Creusé, D. Depeyras, P. Gilliéron, I. Mortazavi   +4 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Investigation on the Impact of Air Admission in a Prototype Francis Turbine at Low-Load Operation

Energies, 2019
Due to significant changes in the energy system, hydraulic turbines are required to operate over a wide power range. In particular, older turbines which are not designed for these environments will suffer under off-design conditions. In order to evaluate
Julian Unterluggauer, Anton Maly, Eduard Doujak   +2 more
doaj   +1 more source

Active Flow Control and Dynamic Analysis in Droplet Microfluidics. [PDF]

Annu Rev Anal Chem (Palo Alto Calif), 2021
Shi N, Mohibullah M, Easley CJ.
europepmc   +1 more source