Results 41 to 50 of about 1,002,819 (265)

Quantitative Analysis of Drag Reduction Methods for Blunt Shaped Automobiles

open access: yesApplied Sciences, 2020
In fluid mechanics, drag related problems aim to reduce fuel consumption. This paper is intended to provide guidance for drag reduction applications on cars.
Ferenc Szodrai
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Investigations on the Potentials of Novel Technologies for Aircraft Fuel Burn Reduction through Aerostructural Optimisation

open access: yesAerospace, 2022
A physics-based optimisation framework is developed to investigate the potential advantages of novel technologies on the energy efficiency of a midrange passenger aircraft.
Valerio Mosca, Ali Elham
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Verification of Boundary Conditions Applied to Active Flow Circulation Control

open access: yesAerospace, 2019
Inclusion of Active Flow Control (AFC) into Computational Fluid Dynamics (CFD) simulations is usually highly time-consuming and requires extensive computational resources and effort.
Petr Vrchota   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

In-sewer sedimentation associated with active flow control

open access: yesWater Science and Technology, 2009
Active flow control using automated gates and weirs aims to utilise available dispersed storage within sewer systems to alleviate the severity and frequency of localised flooding incidents. Whilst a previous study has demonstrated its potential, a key operational concern before implementation was sedimentation. An experimental programme was designed to
K J, Williams, S J, Tait, R M, Ashley
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Aerodynamic Drag Reduction and Optimization of MIRA Model Based on Plasma Actuator

open access: yesActuators, 2020
Active flow control of surface dielectric barrier discharge (SDBD) plasma is a technology that converts electrical energy into kinetic energy to achieve flow control. Its main application areas are concentrated in the aviation field.
Chenguang Lai   +4 more
doaj   +1 more source

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