Results 101 to 110 of about 1,024,804 (310)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Smart double panel with decentralised active dampers for control of sound transmission
, 2007 This report presents the results of a theoretical study of active sound transmission control through a double panel. The double panel material and geometrical properties have been chosen so as to emulate section of an aircraft fuselage, or bodywork of a ...
Gardonio, Paolo +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A power flow mode theory based on a system's damping distribution and power flow design approaches [PDF]
, 2005 A power flow mode theory is developed to describe the natural power flow behaviour of a dynamic system based on its inherent damping distribution.
Xing, J.T. +5 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Study of active flow control for a simplified vehicle model using the PANS method
, 2013 Flow control has shown a potential in reducing the drag in vehicle aerodynamics. The present numerical study deals with active flow control for a quasi-2D simplified vehicle model using a synthetic jet (zero net mass flux jet).
Basara, B., +5 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Analysis and control of resonant cavity flows [PDF]
, 2013 Recently, the trend for the internalisation of stores within an aircraft fuselage has led to a renewed interest in the field of cavity aero-acoustics.
Roberts, David
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Adaptive Separation Control System Using Vortex Generator Jets for Time-Varying Flow
Journal of Applied Fluid Mechanics, 2008 Flow separation is mostly an undesirable phenomenon and boundary layer control is an important technique for flow separation problems on airfoils and in diffusers.
H Hasegawa, S Kumagai
doaj