Results 171 to 180 of about 339,788 (346)

Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice

open access: yesAging Cell, EarlyView.
Transcriptomic analyses reveal an age‐related decline in autophagy pathways in RPE/choroid. These pathways remain unchanged in early AMD but become bidirectionally dysregulated in later stages, along with increased RPE loss. Pre‐treatment with trehalose eyedrops enhances RPE autophagy flux and prevents light‐induced outer retinal degeneration in mice ...
Katherine Cox   +13 more
wiley   +1 more source

Core Revelations: The Star Formation and Active Galactic Nucleus Connection at the Heart of NGC 7469

open access: yesThe Astrophysical Journal
We investigate the star formation–active galactic nucleus (AGN) connection in the Seyfert 1 NGC 7469 using James Webb Space Telescope mid-infrared spectroscopic integral field unit (IFU) data.
Léa M. Feuillet   +6 more
doaj   +1 more source

High-redshift galaxies, their active nuclei and central black holes [PDF]

open access: green, 1998
Martin G. Haehnelt   +2 more
openalex   +1 more source

Active galaxies and the diffuse Gamma-Ray background [PDF]

open access: yes
A model for the origin of relativistic particles and gamma rays in active galactic nuclei and quasars, together with recent HEAO-1 observations of the spectra of active galaxies from 2 to 165 keV, provide the basis for a reexamination of the nature of ...
Kazanas, D., Protheroe, R. J.
core   +1 more source

Has Politics Become More Professional? Career and Legislative Professionalisation in the Australian Parliament Since 1950

open access: yesAustralian Journal of Politics &History, EarlyView.
“Professional politicians” have been lamented for their perceived negative impact on representative democracy. However, the concept of “political professionalisation” is deployed inconsistently, making these claims difficult to assess. This article develops a framework to measure professionalisation across two dimensions: career professionalisation ...
Peter Ferguson   +3 more
wiley   +1 more source

Computers and chess masters: The role of AI in transforming elite human performance

open access: yesBritish Journal of Psychology, EarlyView.
Abstract Advances in Artificial Intelligence (AI) have made significant strides in recent years, often supplementing rather than replacing human performance. The extent of their assistance at the highest levels of human performance remains unclear. We analyse over 11.6 million decisions of elite chess players, a domain commonly used as a testbed for AI
Merim Bilalić, Mario Graf, Nemanja Vaci
wiley   +1 more source

(2R,6R)‐hydroxynorketamine prevents opioid abstinence‐related negative affect and stress‐induced reinstatement in mice

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Opioid use disorder (OUD) is a pressing public health concern marked by frequent relapse during periods of abstinence, perpetuated by negative affective states. Classical antidepressants or the currently prescribed opioid pharmacotherapies have limited efficacy to reverse the negative affect or prevent relapse ...
Andria Michael   +7 more
wiley   +1 more source

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