Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
THE ECONOMIC EFFECTS OF IRRIGATION AND DUNGING IN THE SUGAR-BEET PRODUCTION
Ekonomika Poljoprivrede (1979), 2010 The research of production and economic effects of irrigation to the sugarbeet and sugar growth per hectare was carried out on the carbonate humus of favourable water-physical and chemical characteristics on the location of Rimski Šančevi during the ...
Livija Maksimović +3 more
doaj
Active Management of Labor Process under Smart Medical Model Improves Vaginal Delivery Outcomes of Pregnant Women with Preeclampsia. [PDF]
J Healthc Eng, 2022 Xin S +9 more
europepmc +1 more source
Catch Shares in Action: Samoan Safata District Customary User Rights Program [PDF]
, 2013 The Samoan Customary User Rights System is an area-based catch share program that formalizes the customary fishing rights of native communities. Authorized by legislative reforms, fishing communities voluntarily establish and manage Territorial Use ...
Jeff Young
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Therapeutic outcome of active management in male patients with detrusor underactivity based on clinical diagnosis and videourodynamic classification. [PDF]
Sci Rep, 2022 Lee CL +5 more
europepmc +1 more source
Activation/waste management [PDF]
, 1984 The selection of materials and the design of the blankets for fusion reactors have significant effects upon the radioactivity generated by neutron activation in the materials. This section considers some aspects of materials selection with respect to waste management.
openaire +2 more sources
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Experiences managing pregnant hospital staff members using an active management policy-A qualitative study. [PDF]
PLoS One, 2021 Backhausen MG +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source