Results 51 to 60 of about 905,153 (261)

Observer-based control for active suspension system with time-varying delay and uncertainty

Advances in Mechanical Engineering, 2019
Time-varying input delay of actuators, uncertainty of model parameters, and input and output disturbances are important issues in the research on active suspension system of vehicle.
Kuiyang Wang, Ren He, Heng Li, Jinhua Tang, Ruochen Liu, Yangmin Li, Ping He   +6 more
doaj   +1 more source

Activation of cartilage matrix metalloproteinases by activated protein C [PDF]

Arthritis & Rheumatism, 2009
AbstractObjectiveTo investigate the role of activated protein C (APC) in cartilage degradation.MethodsChondrocyte expression of protein C, endothelial protein C receptor (EPCR), and thrombomodulin (TM) were evaluated by reverse transcription–polymerase chain reaction (RT‐PCR).
Miriam T, Jackson, Margaret M, Smith, Susan M, Smith, Christopher J, Jackson, Meilang, Xue, Christopher B, Little   +5 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Synergetic effects of nano-boehmite and Y nano-zeolite on catalytic cracking of residue oil

Scientific Reports
Boehmite nanoparticles and NaY nanozeolite were synthesized by co-precipitation and hydrothermal methods, respectively, and characterized by XRD, FT-IR, TG-DTA, BET, and SEM techniques.
Ehsan Amini, Kamran Ahmadi, Alimorad Rashidi, Amir Ali Youzbashi, Mehran Rezaei, Sakineh Mesgar   +5 more
doaj   +1 more source

Phytic acid modified polycaprolactone electrospun matrix for active nerve regeneration

Results in Chemistry
Physicochemical modification of biomaterials has enormous potential for enhanced functionality and applications. Phytic acid (PA) is a sustainable, non-toxic, and environmentally friendly material used for surface modification in different applications ...
Ganesh Prasad Awasthi, Arjun Prasad Tiwari, Miyeon Shin, Krishna Prasad Sharma, In Hong Yang, Changho Yu   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Nanoscale Structural Plasticity of the Active Zone Matrix Modulates Presynaptic Function

Cell Reports, 2017
The active zone (AZ) matrix of presynaptic terminals coordinates the recruitment of voltage-gated calcium channels (VGCCs) and synaptic vesicles to orchestrate neurotransmitter release.
Oleg O. Glebov, Rachel E. Jackson, Christian M. Winterflood, Dylan M. Owen, Ellen A. Barker, Patrick Doherty, Helge Ewers, Juan Burrone   +7 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source