Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Role of kinematic constraints in the time reversal symmetry breaking of a model active matter. [PDF]
PNAS NexusDas S, Ghosh S, Sadhu T, Klamser JU.
europepmc +1 more source
Dry, aligning, dilute, active matter: A synthetic and self-contained\n overview [PDF]
, 2019 Hugues Chaté, Benoît Mahault
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Using active matter to introduce spatial heterogeneity to the susceptible infected recovered model of epidemic spreading. [PDF]
Sci Rep, 2022 Forgács P +4 more
europepmc +1 more source
On Kinetic Equations for Collisional Dynamics of Active Soft Condensed Matter [PDF]
, 2017 V. I. Gerasimenko
openalex +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
The effect of self-induced Marangoni flow on polar-nematic waves in active-matter systems. [PDF]
Eur Phys J E Soft MatterPototsky A, Thiele U.
europepmc +1 more source