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Continuous-Flow Chemistry and Photochemistry for Manufacturing of Active Pharmaceutical Ingredients [PDF]

Molecules, 2022
An active pharmaceutical ingredient (API) is any substance in a pharmaceutical product that is biologically active. That means the specific molecular entity is capable of achieving a defined biological effect on the target. These ingredients need to meet
Pavlína Horáková, Kamila Kočí
doaj   +4 more sources

Multicomponent Reactions for the Synthesis of Active Pharmaceutical Ingredients [PDF]

Pharmaceuticals, 2022
Multicomponent reactions 9i.e., those that engage three or more starting materials to form a product that contains significant fragments of all of them), have been widely employed in the construction of compound libraries, especially in the context of ...
Ángel Cores, José Clerigué, Emmanuel Orocio-Rodríguez, J. Carlos Menéndez   +3 more
doaj   +2 more sources

Modification of the Physicochemical Properties of Active Pharmaceutical Ingredients via Lyophilization. [PDF]

Pharmaceutics, 2023
Taldaev A, Pankov DI, Terekhov RP, Zhevlakova AK, Selivanova IA.   +4 more
europepmc   +2 more sources

Highly selective kinetic resolution of D/L-syn-p-sulfone phenylserine catalyzed by d-threonine aldolase in two-phase ionic solvent

Green Chemical Engineering, 2023
In the chemical synthesis of L-syn-p-methylsulfoxide phenylserine ethyl ester (D-ethyl ester), l-tartaric acid or enzymatic resolution is employed to resolve the racemate, and thus obtain the target compound, and the remaining isomer can be recycled to ...
Fengfan Liu, Zhihao Shi, Jinmei Zhu, Xiaobin Liang, Mingming Liang, Yuanyuan Xie, Weike Su, Jiequn Wu   +7 more
doaj   +1 more source

An Efficient Continuous Flow Synthesis for the Preparation of N-Arylhydroxylamines: Via a DMAP-Mediated Hydrogenation Process

Molecules, 2023
The selective hydrogenation of nitroarenes to N-arylhydroxylamines is an important synthetic process in the chemical industry. It is commonly accomplished by using heterogeneous catalytic systems that contain inhibitors, such as DMSO.
Jianli Chen, Xinyu Lin, Feng Xu, Kejie Chai, Minna Ren, Zhiqun Yu, Weike Su, Fengfan Liu   +7 more
doaj   +1 more source

Ionic Liquids as Active Pharmaceutical Ingredients [PDF]

ChemMedChem, 2011
AbstractIonic liquids (ILs) are ionic compounds that possess a melting temperature below 100 °C. Their physical and chemical properties are attractive for various applications. Several organic materials that are now classified as ionic liquids were described as far back as the mid‐19th century.
Ferraz, Ricardo, Branco, Luís C., Prudêncio, Cristina, Noronha, João Paulo, Petrovski, Željko   +4 more
openaire   +3 more sources

State of the art and applications in nanostructured biocatalysis

Biotechnology & Biotechnological Equipment, 2022
Enzymes have been widely studied for their excellent efficiency, selectivity and environmentally benign nature. However, the development of their biocatalytic applications is severely limited by the lack of stability and reusability.
Fengfan Liu, Zhihao Shi, Weike Su, Jiequn Wu   +3 more
doaj   +1 more source

Hibiscus sabdariffa extract/poly (vinyl alcohol) modified magnetite as a magnetically recyclable nanocatalyst for the selective oxidation of amines

Results in Chemistry, 2022
The development of poly (vinyl alcohol)/Hibiscus sabdariffa extract modified silicate-coated Fe3O4 nanoparticles (Fe3O4@SiO2-Hs/PVA) presents an economical and environmental-friendly heterogeneous catalytic system for amines oxidation with hydrogen ...
Pegah Haghighi, Hakimeh Ziyadi, Malak Hekmati, Navid Habibnejad, Sheyda Iranfar   +4 more
doaj   +1 more source

Comparative studies on selection of high polyphenolic containing Chinese raspberry for evaluation of antioxidant and cytotoxic potentials

Journal of Agriculture and Food Research, 2023
The Chinese raspberry (Rubus chingii Hu) fruit is well-recognized for its special pharmacological qualities. We examined the polyphenolic constituents in twelve Chinese raspberries (B1–B12), out of which B1 raspberry showed high content of phenolics ...
Jiajia Su, Li Jin, Ruiwen Yang, Yi Liang, Shivraj Hariram Nile, Guoyin Kai   +5 more
doaj   +1 more source

Active Pharmaceutical Ingredients Transportation and Release from Aerogel Particles Processes Modeling

Computation, 2022
In this work, active pharmaceutical ingredients release from aerogel particles and active pharmaceutical ingredients transportation processes were investigated.
Igor Lebedev, Anastasia Uvarova, Maria Mochalova, Natalia Menshutina   +3 more
doaj   +1 more source