Results 201 to 210 of about 58,249 (258)

Manufacturing Peptides as Active Pharmaceutical Ingredients

Future Medicinal Chemistry, 2009
Today, there are more than 40 peptides on the pharmaceutical world market and more than 100 in several clinical phases. Although in the past the pharmaceutical industries had reduced their interest in peptides research, in recent decades, they have rekindled their interest in peptides as a result of contemporary novel technological accomplishments ...
Aikaterini A, Zompra, Athanassios S, Galanis, Oleg, Werbitzky, Fernando, Albericio   +3 more
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Continuous Isolation of Active Pharmaceutical Ingredients

2020
In this chapter the essential underlying science and engineering of filtration, washing and drying are outlined as a basis for identifying best practice. Subsequently the available continuous process equipment variants used in the pharmaceutical and associated industry sectors are described and their potential fit into a pharmaceutical context is ...
Price, Chris John, Barton, Alastair, Coleman, Simon   +2 more
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Active Pharmaceutical Ingredients

2005
Introduction. Process Development. Technology Transfer. Plant Design & Construction. Regulatory Requirements. Process Validation. Quality Assurance and Control. Plant Operations. Materials Management.
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Precision Active Pharmaceutical Ingredients are the Goal

Future Medicinal Chemistry, 2016
Understanding and exploiting molecular mechanisms in biology is central to chemical biology. Chemical biology studies of biological macromolecules are now in a perfect continuum with molecular level and nanomolecular level mechanistic studies involving whole organisms.
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Polymorphism of Active Pharmaceutical Ingredients

Chemical Engineering & Technology, 2006
AbstractDifferent polymorphs of the same active pharmaceutical ingredient (API) display distinct physical properties, such as melting point, solubility, dissolution rate, hygroscopicity, or stability. The ability to successfully produce and reproduce specific stable polymorphs is intricately correlated with the efficiency and speed of drug development,
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Investigation of active pharmaceutical ingredient loss in pharmaceutical compounding of capsules

Journal of Pharmaceutical and Biomedical Analysis, 2014
Pharmaceutical compounding of capsules is still an important corner stone in today's health care. It allows for a more patient specific treatment plan as opposed to the "one size fits all"-approach, used by the pharmaceutical industry when producing fixed dose finished drug products. However, loss of active pharmaceutical ingredient (API) powder during
Matthias, D'Hondt, Evelien, Wynendaele, Kirsten, Vandercruyssen, Tiene, Bauters, Johan, Vandenbroucke, Steven, Mullens, Chris, Vervaet, Jean Paul, Remon, Bart, De Spiegeleer   +8 more
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Stable isotopic characterization of active pharmaceutical ingredients

Journal of Pharmaceutical and Biomedical Analysis, 2004
Stable isotopic characterization or "fingerprinting" of active pharmaceutical ingredients (APIs) is a highly-specific means of defining the provenance of these pharmaceutical materials. The isotopic analysts in this study were provided with 20 blind samples of four APIs (tropicamide, hydrocortisone, quinine HCL, and tryptophan) from one-to-five ...
J P, Jasper, B J, Westenberger, J A, Spencer, L F, Buhse, M, Nasr   +4 more
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active (pharmaceutical) ingredient (API)

2009
Pharmacologically active part(s) of a formulation; in case of a salt, the active ingredient should be understood to include both, the therapeutic moiety and the appended portion of the molecule; the maximum acceptable deviation in the a.i. content of a finished product must not exceed ±5% at the time of manufacture → see also drug, medicinal product.
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Excipients and Active Pharmaceutical Ingredients

2014
Raw materials in pediatric formulations such as excipients, food ingredients, and active pharmaceutical ingredients (APIs) have received significant attention from regulatory agencies worldwide in recent times due to safety concerns. Not all excipients and food ingredients are “inert” and have been shown to interfere with the growth and development ...
Parnali Chatterjee, Mohammed M. Alvi
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Milling of Active Pharmaceutical Ingredients

2013
Physical properties of active pharmaceutical ingredients (APIs) can impact their effectiveness in the body and influence formulation development and design. In most cases, it is necessary to reduce particle size, which is frequently accomplished by comminution or milling.
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