ACTIVE AGEING IN THE EU 27: HOW TO OVERCOME DIGITAL (LANGUAGE) DIVIDE
Dijete i Obitelj u Suvremenom DruštvuContemporary European societies are facing a growing ratio of older people within the overall demographic structure of the European Union, a trend affecting societal changes in aspects of personal, family and social life with shifts in individual needs ...
Evelin Čanji +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Effects on Respiratory Pressures, Spirometry Biomarkers, and Sports Performance after Inspiratory Muscle Training in a Physically Active Population by Powerbreath®: A Systematic Review and Meta-Analysis. [PDF]
Biology (Basel), 2022 Fernández-Lázaro D +8 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Dividing active and passive particles in nonuniform nutrient environments
New Journal of PhysicsTo explore the coupling between a growing population of microorganisms such as E. coli and a nonuniform nutrient distribution, we formulate a minimalistic model.
Till Welker, Holger Stark
doaj +1 more source
Sunlight exposure and eye disorders in an economically active population: data from the KNHANES 2008-2012. [PDF]
Ann Occup Environ Med, 2021 Lee J +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Associations between individual and environmental determinants and physical activity levels of an active population during the Spanish lockdown. [PDF]
Prev Med, 2021 Gonzalo-Encabo P +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Evaluation of an active population-based surveillance system for major birth defects in South Carolina. [PDF]
Birth Defects Res, 2021 Samson ME +4 more
europepmc +1 more source