Results 111 to 120 of about 192 (168)

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Black phosphorus‐based photothermal disruption of cancer‐associated fibroblast barriers and tumor‐associated macrophage targeting to enhance anti‐PD‐L1 immunotherapy in triple‐negative breast cancer

Interdisciplinary Medicine, EarlyView.
MBB modulates the TNBC tumor microenvironment by targeting TAM/CXCL1 and facilitates anti‐PD‐L1 therapy by disrupting CAF barriers via its photothermal effect. This combined strategy subsequently enhances the efficacy of PD‐L1 mAb and suppresses TNBC progression, metastasis, and recurrence.
Bo Pan, Shicui Hong, Xinyue Wang, Yanghang Li, Cai Wang, Yaxiao Liu, Ying Chen, Chen Fang, Yifeng Zheng, Shengqi Wang, Juping Zhang, Neng Wang, Zhiyu Wang   +12 more
wiley   +1 more source

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, EarlyView.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Application of Magnesium Metal as Anode in Batteries

MetalMat, EarlyView.
When used as an anode, magnesium metal offers several advantages, including a high volumetric capacity, environmental friendliness, abundant natural reserves, and a low tendency for dendrite growth. Battery types employing magnesium as the anode include rechargeable magnesium‐ion batteries, aqueous magnesium‐ion batteries, magnesium–air batteries, and ...
Yuanjie Zhang, Dichang Guan, Guorong Hu, Zhongdong Peng, Yanbing Cao, Ke Du   +5 more
wiley   +1 more source

Corrosion and Passivation: An Intimate Struggle for Durable Non‐Aqueous Multivalent Metal Batteries

National Materials, EarlyView.
In multivalent metal batteries, corrosion and passivation are intrinsically coupled. Anodes and current collectors pose conflicting interfacial demands: ion‐ versus electron‐conductivity. This review deciphers their intricate interplay and discusses current strategies to balance these mechanisms for achieving durable battery performance.
Hongfeng Chen, Bo Zhang, Xinyue Zhang, Daliang Han, Zhe Weng, Quan‐Hong Yang   +5 more
wiley   +1 more source

Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease

Neuroprotection, EarlyView.
In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong, Andrew Octavian Sasmita, Rhun Yian Koh, Anna Pick Kiong Ling   +3 more
wiley   +1 more source

Artificial-Intelligence-Enhanced Analysis of In Vivo Confocal Microscopy in Corneal Diseases: A Review. [PDF]

Diagnostics (Basel)
Kryszan K, Wylęgała A, Kijonka M, Potrawa P, Walasz M, Wylęgała E, Orzechowska-Wylęgała B.   +6 more
europepmc   +1 more source

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, EarlyView.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

Endogenous self-peptides guard immune privilege of the central nervous system. [PDF]

Nature
Kim MW, Gao W, Lichti CF, Gu X, Dykstra T, Cao J, Smirnov I, Boskovic P, Kleverov D, Salvador AFM, Drieu A, Kim K, Blackburn S, Crewe C, Artyomov MN, Unanue ER, Kipnis J.   +16 more
europepmc   +1 more source

Urban Heat and Spatial Statistics, Toward Sustainable Cities and Society: A PRISMA‐Based Systematic Review and Empirical Assessment (2020–2025)

Sustainable Development, EarlyView.
ABSTRACT Over the past few decades, the intensification of global warming has brought increased attention to urban thermal dynamics, particularly regarding Land Surface Temperature (LST) and the Urban Surface Heat Island (SUHI) effect. This study conducts a systematic literature review alongside a bibliometric analysis of 123 peer‐reviewed articles ...
David Hidalgo‐García, Hamed Rezapouraghdam, Antonio Jesús Aguilar‐Aguilera, María Luísa de la Hoz‐Torres, Rubén López‐Cantero   +4 more
wiley   +1 more source