Results 31 to 40 of about 437,703 (216)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

REDUCTION OF ACTIVE POWER LOSS BY IMPROVED FROG LEAPING ALGORITHM

open access: yesInternational Journal of Research -GRANTHAALAYAH, 2017
This paper presents Improved Frog Leaping (IFL) algorithm for solving optimal reactive power problem.  Comprehensive exploration capability of Particle Swarm Optimization (PSO) and   good local search ability of Frog Leaping Algorithm (FLA) has been hybridized to solve the reactive power problem and it overcomes the shortcomings of premature ...
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

ENHANCED SEEKER OPTIMIZATION ALGORITHM FOR REDUCTION OF ACTIVE POWER LOSS

open access: yesInternational Journal of Research -GRANTHAALAYAH, 2017
This paper projects Enhanced Seeker Optimization (ESO) algorithm for solving optimal reactive power problem. Seeker optimization algorithm (SOA) models the deeds of human search population based on their memory, experience, uncertainty reasoning and communication with each other.
openaire   +3 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

ACTIVE POWER LOSS REDUCTION BY AMPLIFIED ANT COLONY ALGORITHM

open access: yesInternational Journal of Research -GRANTHAALAYAH, 2018
In this paper, Amplified Ant Colony (AAC) algorithm has been proposed for solving optimal reactive power problem. Mutation of Genetic algorithm (GA) is used in Ant Colony Algorithm (ACA) and the output of the GA is given as an input to the ACA. The proposed Amplified Ant Colony (AAC) algorithm has been tested on standard IEEE 118 & practical 191 ...
openaire   +3 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

REDUCTION OF ACTIVE POWER LOSS BY IMPROVED TABU SEARCH ALGORITHM

open access: yesInternational Journal of Research -GRANTHAALAYAH, 2018
In this paper, an Improved Tabu Search (ITS) algorithm has been proposed to solve the optimal reactive power problem. In this work Tabu Search- has been hybridized with Simulated Annealing algorithm to solve the optimal reactive power problem. Hybridization of these two algorithms improves the exploration & exploitation capabilities during the ...
openaire   +3 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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