Results 111 to 120 of about 601,728 (351)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Politics and the Church. A segregational marriage that affects national integrity
Sfera Politicii, 2015 Since 1989 Revolution, Romania has gone through many rounds of presidential elections. However, none of these has ever divided the country map according to preferences before.
Viorel Mionel
doaj
Holistic Tourist Experiences in Mature Destinations [PDF]
Journal of Emerging Trends in Marketing and Management, 2019 Tourism is one of the activities that most urgently requires innovation and creativity to keep its constantly booming. The aim of this paper is to figure out how mature destinations and their tourist managers provide innovative and sustainable actions in
Montserrat Crespi-Vallbona +1 more
doaj
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Once despised now desired: innovative land use and management of multilayered Pumice Soils in the Taupo and Galatea areas, central North Island, New Zealand [PDF]
, 2014 The tour brings together innovative land use change and management associated with dairy farming, and land-based effluent disposal, on weakly weathered and multi-layered, glass-rich, Pumice Soils (Vitrands) in the Taupo and Galatea areas.
Balks, Megan R. +2 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source