Results 51 to 60 of about 84,174 (266)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

The development of traffic competences - do children need special infrastructure to be safe in traffic?

Transactions on Transport Sciences, 2018
A lot of (visual, auditory, social, emotional, psycho-motoric, intellectual and cognitive) competences are needed for safe traffic participation. Traffic competences develop during childhood and youth and there is a close relationship to brain maturity ...
B. Schützhofer, J. Rauch, J. Stark
doaj   +1 more source

Research on integrated simulation platform for urban traffic control connecting simulation and practice

Scientific Reports, 2022
Though effective in theoretical simulation, the established traffic control models and optimization algorithms will result in model mismatch or even control strategy failure in actual application.
Lili Zhang, Qi Zhao, Pei Yu, Jing Li, Di Yao, Xinzhe Wang, Li Wang, Lingyu Zhang   +7 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

A Fluorogen-Activating Biosensor for Analysis of BK Channel Traffic and Surface Residency [PDF]

Biophysical Journal, 2015
The regulation of ion channels is critical to numerous physiological processes, especially neuronal function. The large conductance voltage and calcium-activated potassium (BK) channel can modulate neuronal excitability, neurotransmitter release, and may be involved in the development of epilepsy; following a seizure, hippocampal BK channels are more ...
Pratt, Christopher, He, Jianjun, Barth, Alison, Bruchez, Marcel   +3 more
openaire   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Application of Neural Networks to Analyse the Spatial Distribution of Bicycle Traffic Before, During and After the Closure of the Mill Road Bridge in Cambridgeshire, United Kingdom

Sensors
Traffic congestions due to construction and maintenance works of road infrastructure cause travel delays, unpredictability and less tolerant road users. Bicyclists are more flexible with road closures, shifting to alternative routes, public transport and
Shohel Amin
doaj   +1 more source

Prediction of dynamics of suspicious network activity based on network traffic analysis

Connectivity, 2022
The article considers the possibility of early prediction of cyberattacks based on the analysis of suspicious activity in the network, which will provide additional opportunities for information protection services in countering such attacks. A feature of a slow DDoS attack is the use of a vulnerability in the TCP protocol, where interruptions can be ...
openaire   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source