Results 121 to 130 of about 2,374,890 (276)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Stimuli‐Responsive Nanocarriers for Transcytosis‐Based Cancer Drug Delivery

Advanced NanoBiomed Research
Significant challenges persist in enhancing the delivery efficiency of tumor nanomedicines, predominantly due to the difficulty of successfully surpassing pathophysiological barriers.
Zhehao Wang, Yuji Sun, Youqing Shen, Zhuxian Zhou   +3 more
doaj   +1 more source

ENERGY expenditure of COmmuting to school (ENERGYCO): protocol for a cluster randomized controlled trial

Frontiers in Public Health
IntroductionThis article outlines the rationale and methodology of the ENERGY expenditure of COmmuting to school study (the ENERGYCO study), a cluster-randomized controlled trial. The ENERGYCO study is divided into two phases: Phase I will aim; to assess
Pablo Campos-Garzón, Pablo Campos-Garzón, Víctor Manuel Valle-Muñoz, José Manuel Segura-Díaz, Manuel Ávila-García, Manuel Ávila-García, Romina Gisele Saucedo-Araujo, Romina Gisele Saucedo-Araujo, Ana Ruiz-Alarcón, Francisco David López-Centeno, Unai A. Pérez De Arrilucea Le Floc’h, Juan M. A. Alcantara, Juan M. A. Alcantara, Juan M. A. Alcantara, Luis Miguel Medel-Carbonell, David Rodriguez-Sanchez, Ana Ramírez-Osuna, Marina Castillo-Barragán, Estela Águila-Lara, Francisco Javier Huertas-Delgado, Manuel Herrador-Colmenero, Sandra Mandic, Sandra Mandic, Palma Chillón, Yaira Barranco-Ruiz, Emilio Villa-González   +25 more
doaj   +1 more source

A summary of the application of active controls technology in the ATT system studies [PDF]

The application of active controls technology to subsonic, long-range transport aircraft was investigated in three Advanced Transport Technology system studies.
Hood, R. V.
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Active Transport

The American Biology Teacher, 1986
Charles R. Barman, Nevin E. Longenecker, E. Thomas Hibbs   +2 more
openaire   +2 more sources

Application of Surface Electromyography (sEMG) in the Analysis of Upper Limb Muscle Activity in Women Aged 50+ During Torqway Riding

Sensors
The aim of this study was to analyze the activation of selected upper limb muscles. For the purposes of this article, we present results concerning the following muscles: triceps brachii, anterior and posterior deltoid, and trapezius in women aged 50 and
Sylwia Agata Bęczkowska, Iwona Grabarek, Zuzanna Zysk   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Barriers and Facilitators to Cycling to School for Children in the UK: A Systematic Review

Active Travel Studies
The benefits of cycling as a means of active transport are well known, and there is recent UK Government interest in promoting cycling. Few children in the UK cycle to school, and little research has explored the factors that affect this. This systematic
Cath Larkins, Deborah Crook, Joanne Westwood, Julie Ridley, Kennedy Dominic Tellis, Mags Adams, Paul Boland, Rebecca Nowland   +7 more
doaj   +2 more sources