Results 51 to 60 of about 2,374,890 (276)

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

Experimental and Computational Methods to Assess Central Nervous System Penetration of Small Molecules

Molecules
In CNS drug discovery, the estimation of brain exposure to lead compounds is critical for their optimization. Compounds need to cross the blood–brain barrier (BBB) to reach the pharmacological targets in the CNS.
Mayuri Gupta, Jun Feng, Govinda Bhisetti
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Micro-Level Bicycle Infrastructure Design Elements: A Framework for Developing a Bikeability Index for Urban Areas

Smart Cities
Modern and smart cities prioritize providing sufficient facilities for inclusive and bicycle-friendly streets. Several methods have been developed to assess city bicycle environments at street, neighborhood, and city levels.
Tufail Ahmed, Ali Pirdavani, Geert Wets, Davy Janssens   +3 more
doaj   +1 more source

Generalized Einstein or Green-Kubo relations for active biomolecular transport

, 2010
For driven Markovian dynamics on a network of (biomolecular) states, the generalized mobilities, i.e., the response of any current to changes in an external parameter, are expressed by an integral over an appropriate current-current correlation function ...
N. Kikuchi, R. Kubo, Udo Seifert
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Facilitation of polymer looping and giant polymer diffusivity in crowded solutions of active particles

New Journal of Physics, 2015
We study the dynamics of polymer chains in a bath of self-propelled particles (SPP) by extensive Langevin dynamics simulations in a two-dimensional model system.
Jaeoh Shin, Andrey G Cherstvy, Won Kyu Kim, Ralf Metzler   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Transport on a Lattice with Dynamical Defects [PDF]

, 2013
Many transport processes in nature take place on substrates, often considered as unidimensional lanes. These unidimensional substrates are typically non-static: affected by a fluctuating environment, they can undergo conformational changes.
Andrea Parmeggiani, B. Alberts, B. Schmittmann, Estelle Pitard, Francesco Turci, G. Schutz, Luca Ciandrini, M. Carmen Romano   +7 more
core   +6 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source