Results 91 to 100 of about 14,136,893 (299)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Fossil Fuels: Natural Gas [PDF]

This lesson provides an introduction to the use of natural gas as an energy source. Topics include its advantages (cleanliness, fewer carbon emissions), disadvantages (difficulty in transport and storage), sources, and usage.
John Pratte
core  

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Shifting national surveillance of Shigella infections toward geno‐serotyping by the development of a tailored Luminex assay and NGS workflow

MicrobiologyOpen, 2019
The phylogenetically closely related Shigella species and enteroinvasive Escherichia coli (EIEC) are responsible for millions of episodes of bacterial dysenteriae worldwide.
Eleonora Ventola, Bert Bogaerts, Sigrid C. J. De Keersmaecker, Kevin Vanneste, Nancy H. C. Roosens, Wesley Mattheus, Pieter‐Jan Ceyssens   +6 more
doaj   +1 more source

Home Energy Audit [PDF]

This is the first part of a two-part exercise in which students perform an audit and analysis of energy consumption in their homes. This part provides an introduction to the uses of energy in our homes. Topics include major uses in the home (heating, air
John Pratte
core  

CBERN - The First Six Years: Challenges and Achievements [PDF]

, 2012
CBERN was created in 2006. Its mandate was to create a network able to address critically, persuasively and visibly the foundational role of ethics in business and economic development. The task facing the network was significant. The field was fractured
Canadian Business Ethics Research Network (CBERN)
core  

Colorimetric Method for the Quantitative Determination of Plasma Catalase Activity [PDF]

, 1958
Gerald Dobkin, Morton D. Glantz
openalex   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

ACADEMIC MOBILITY: FACTORS OF DEVELOPMENT AND TRANSFORMATION

Высшее образование в России, 2017
The article introduces the up-to-date research in academic mobility and the prospects for its development. Much attention is given to the factors of influence and contemporary trends in international education.
A. Yu. Kuznetsov, E. V. Vershinina
doaj