Results 141 to 150 of about 23,920,837 (347)
Central to good science are accurate observations, testable hypotheses, well-designed experiments or other tests, and reasonable data analyses. The purpose of this activity is to introduce the basics of designing and analyzing experiments.
Matthew Laposata
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Technology Teacher: Singing the Black and Blues [PDF]
, 2004 Gives simple, yet authoritative answers to the questions "Why is the sky blue?" and "Why is the sky black at night?" Combines technology with its application to Earth science, astronomy, and cosmology, and does so via language arts and music!
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
The transport and transformation of substances in the environment are known collectively as biogeochemical cycles. These global cycles involve the circulation of elements and nutrients that sustain both the biological and physical aspects of the ...
John Pratte
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
This two-part activity provides an introduction to the basics of measurement (linear, mass, volume, density) and discusses the role of inferential statistics in comparing any two measurements.
Matt Laposata
core
Teaching activity illustrates how levees on the Mississippi River exacerbated flood damage in St. Louis during the Great Flood of l993. Students build a model of a river system and observe the results of flooding without levees, with wetlands (sponges ...
core +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source